Analysis of Phosphonic Acids: Validation of Semi-Volatile Analysis by HPLC-MS/MS by EPA Method MS999

Owens, J ; Vu, A ; Koester, C

关键词: ENVIRONMENTAL PROTECTION;    HYDROGEN;    LAWRENCE LIVERMORE NATIONAL LABORATORY;    MASS SPECTROSCOPY;    METRICS;    MONITORING;    PERFORMANCE;    PHOSPHONIC ACIDS;    QUALITY CONTROL;    SECURITY;    US EPA;    VALIDATION;    WATER;   

DOI  :  10.2172/945524
RP-ID  :  LLNL-TR-408554
PID  :  OSTI ID: 945524
Others  :  TRN: US200904%%75

学科分类：化学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

The Environmental Protection Agency's (EPA) Region 5 Chicago Regional Laboratory (CRL) developed a method titled Analysis of Diisopropyl Methylphosphonate, Ethyl Hydrogen Dimethylamidophosphate, Isopropyl Methylphosphonic Acid, Methylphosphonic Acid, and Pinacolyl Methylphosphonic Acid in Water by Multiple Reaction Monitoring Liquid Chromatography/Tandem Mass Spectrometry: EPA Version MS999. This draft standard operating procedure (SOP) was distributed to multiple EPA laboratories and to Lawrence Livermore National Laboratory, which was tasked to serve as a reference laboratory for EPA's Environmental Reference Laboratory Network (ERLN) and to develop and validate analytical procedures. The primary objective of this study was to validate and verify the analytical procedures described in EPA Method MS999 for analysis of the listed phosphonic acids and surrogates in aqueous samples. The gathered data from this validation study will be used to: (1) demonstrate analytical method performance; (2) generate quality control acceptance criteria; and (3) revise the SOP to provide a validated method that would be available for use during a homeland security event. The data contained in this report will be compiled, by EPA CRL, with data generated by other EPA Regional laboratories so that performance metrics of EPA Method MS999 can be determined.