Cyclotron Produced Radionuclides for Diagnosis and Therapy of Human Neoplasms

Steven Larson MD

关键词: BIOLOGY;    CYCLOTRONS;    DECAY;    DIAGNOSIS;    NEOPLASMS;    NUCLEAR MEDICINE;    OPTIMIZATION;    PHYSICS;    POSITRONS;    RADIATIONS;    RADIOISOTOPES;    TESTING;    THERAPY;   

DOI  :  10.2172/964282
RP-ID  :  DOE/ER/60407
PID  :  OSTI ID: 964282
Others  :  TRN: US1002786

学科分类：核物理和高能物理

美国|英语

来源: SciTech Connect

【 摘 要 】

This project funded since 1986 serves as a core project for cancer research throughout MSKCC, producing key radiotracers as well as basic knowledge about thel physics of radiation decay and imaging, for nuclear medicine applications to cancer diagnosis and therapy. In recent years this research application has broadened to include experiments intended to lead to an improved understanding of cancer biology and into the discovery and testing of new cancer drugs. Advances in immune based radiotargeting form the basis for this project. Both antibody and cellular based immune targeting methods have been explored. The multi-step targeting methodologies (MST) developed by NeoRex (Seattle,Washington), have been adapted for use with positron emitting isotopes and PET allowing the quantification and optimization of targeted delivery. In addition, novel methods for radiolabeling immune T-cells with PET tracers have advanced our ability to track these cells of prolonged period of time.