DE-FG02-05ER64001 Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors

P.I. Steven M. Larson MD Co P.I. Nai-Kong Cheung MD, Ph.D.

关键词: ANTIGENS;    IN VIVO;    NEOPLASMS;    OPTIMIZATION;    RADIOIMMUNOTHERAPY;    THERAPY;    VALIDATION;   

DOI  :  10.2172/964281
RP-ID  :  DOE/ER/64001
PID  :  OSTI ID: 964281
Others  :  TRN: US1002339

学科分类：放射科、核医学、医学影像

美国|英语

来源: SciTech Connect

【 摘 要 】

The 4 specific aims of this project are: (1) Optimization of MST to increase tumor uptake; (2) Antigen heterogeneity; (3) Characterization and reduction of renal uptake; and (4) Validation in vivo of optimized MST targeted therapy. This proposal focussed upon optimizing multistep immune targeting strategies for the treatment of cancer. Two multi-step targeting constructs were explored during this funding period: (1) anti-Tag-72 and (2) anti-GD2.