Microchannel Reactor System for Catalytic Hydrogenation

Adeniyi Lawal ; Woo Lee ; Ron Besser ; Donald Kientzler ; Luke Achenie

关键词: COMMERCIALIZATION;    DRUGS;    HYDROGENATION;    MANUFACTURING;    PILOT PLANTS;    PROCESSING;    SOLVENTS Microreactor;    Hydrogenation;    Catalysis;   

DOI  :  10.2172/1018952
RP-ID  :  DOE/GO13156-1
PID  :  OSTI ID: 1018952
Others  :  TRN: US201115%%7

学科分类：能源（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

We successfully demonstrated a novel process intensification concept enabled by the development of microchannel reactors, for energy efficient catalytic hydrogenation reactions at moderate temperature, and pressure, and low solvent levels. We designed, fabricated, evaluated, and optimized a laboratory-scale microchannel reactor system for hydrogenation of onitroanisole and a proprietary BMS molecule. In the second phase of the program, as a prelude to full-scale commercialization, we designed and developed a fully-automated skid-mounted multichannel microreactor pilot plant system for multiphase reactions. The system is capable of processing 1 ??? 10 kg/h of liquid substrate, and an industrially relevant immiscible liquid-liquid was successfully demonstrated on the system. Our microreactor-based pilot plant is one-of-akind. We anticipate that this process intensification concept, if successfully demonstrated, will provide a paradigm-changing basis for replacing existing energy inefficient, cost ineffective, environmentally detrimental slurry semi-batch reactor-based manufacturing practiced in the pharmaceutical and fine chemicals industries.