Programmed assembly of nanoscale structures using peptoids.

Ren, Jianhua (University of the Pacific, Stockton, CA) ; Russell, Scott (California State University, Stanislaus, Turlock, CA) ; Morishetti, Kiran (University of the Pacific, Stockton, CA) ; Robinson, David B. ; Zuckermann, Ronald N. (Lawrence Berkeley Nation

关键词: DESIGN;    NANOSTRUCTURES;    NUCLEIC ACIDS;    PEPTIDES;    POLYMERS;   

DOI  :  10.2172/1011204
RP-ID  :  SAND2011-0899
PID  :  OSTI ID: 1011204
Others  :  TRN: US201109%%402

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来源: SciTech Connect

【 摘 要 】

Sequence-specific polymers are the basis of the most promising approaches to bottom-up programmed assembly of nanoscale materials. Examples include artificial peptides and nucleic acids. Another class is oligo(N-functional glycine)s, also known as peptoids, which permit greater sidegroup diversity and conformational control, and can be easier to synthesize and purify. We have developed a set of peptoids that can be used to make inorganic nanoparticles more compatible with biological sequence-specific polymers so that they can be incorporated into nucleic acid or other biologically based nanostructures. Peptoids offer degrees of modularity, versatility, and predictability that equal or exceed other sequence-specific polymers, allowing for rational design of oligomers for a specific purpose. This degree of control will be essential to the development of arbitrarily designed nanoscale structures.