Rapid In Vitro Pathological Diagnosis of Glioma Using Dual‐Color Quantum Dot Probes for Precise Intraoperative Resection

Advanced Science

卷:13

RESEARCH ARTICLE

Dongdong Wu¹  Chenxuan Yang^1,2  Yuanbin Wu³  Minghang Liu^1,2  Yizhi Zhang⁴  Yuang Cai⁴  Yibo Zhang¹  Jimei Chi⁵  Hengchao Ma^1,2  Ding Zhang^1,2  Chenqing Liu⁶  Meng Su⁵  Guochen Sun¹ 

[1] Nankai University School of Medicine, Nankai University, Tianjin, China

[2] Department of Otorhinolaryngology, Head and Neck Surgery, Sixth Medical Center of the Chinese PLA General Hospital, Beijing, China

[3] Department of Neurosurgery, The First Medical Centre, Chinese PLA General Hospital Beijing, Beijing, China

[4] Medical School of Chinese PLA, Beijing, China

[5] Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing Engineering Research Center of Nanomaterials for Green Printing Technology, Beijing National Laboratory for Molecular Sciences (BNLMS), Beijing, China

[6] Department of Emergency Medicine, the Seventh Medical Center, Chinese PLA General Hospital, Beijing, China

关键词: dual‐color probe;    glioma;    perovskite nanocrystal;    precision medicine;   

DOI  :  10.1002/advs.76379

 received in 2026-01-07, accepted in 2026-06-19,  发布年份 2026

来源: Wiley

【 摘 要 】

ABSTRACTBrain gliomas’ variable growth patterns and locations hinder complete surgical removal, while existing clinical imaging/histological methods fail to guide intraoperative resection. To address this, we developed blue‐green dual‐color probes (perovskite quantum dots conjugated to antibodies) targeting glioma cells and IDH1‐mutant simultaneously. These enable rapid intraoperative in vitro pathological diagnosis, helping surgeons devise resection strategies for personalized precise treatment. Tested on 56 clinical frozen sections, the combined detection using dual probes can be completed within 30 min with 91% accuracy: the glioma‐targeting probe identifies tumor boundaries, while the IDH1‐targeting one distinguishes subtypes for optimized margin delineation. We established a personalized resection strategy guided by these results; the dual‐target probes show great potential to assist neurosurgeons in precise glioma resection.

【 授权许可】

CC BY   
© 2026 The Author(s). Advanced Science published by Wiley‐VCH GmbH