mGem: Fungal adhesins in Candidozyma auris confer unique fitness for skin colonization

mBio

卷:17

Perspective

Abishek Balakumar¹  Shankar Thangamani¹ 

[1] Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA

关键词: Candida auris;    adhesins;    skin colonization;    noscomial transmission;   

DOI  :  10.1128/mbio.03805-25

来源: American Society for Microbiology

【 摘 要 】

ABSTRACTCandidozyma auris (formerly Candida auris) is an emerging multidrug-resistant fungal pathogen that causes life-threatening infections in humans. C. auris is distinct from other Candida species and exhibits exceptional capacity for skin colonization, resulting in nosocomial transmission and outbreaks of invasive infections. Fungal adhesins play a crucial role in skin colonization. With this perspective, we discuss the recent advances in the fungal adhesins of C. auris and how the divergence of adhesins in C. auris contributes to its unique fitness for skin colonization. We also discuss potential avenues to target fungal adhesins, which could pave the way for developing novel vaccine strategies and therapeutics to prevent skin colonization, nosocomial transmission, and invasive C. auris infections in humans.

【 授权许可】

CC BY   
Copyright © 2026 Balakumar and Thangamani.

【 图 表 】

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