Nonalcoholic fatty liver disease and cardiovascular disease phenotypes

SAGE Open Medicine

卷:8

Review Paper

Giandomenico Bisaccia¹  Fabrizio Ricci^1,2  Cesare Mantini¹  Claudio Tana³  Gian Luca Romani¹  Cosima Schiavone⁴  Sabina Gallina¹ 

[1] Department of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Technologies, “G. d’Annunzio” University of Chieti and Pescara, Chieti, Italy

[2] Internal Medicine and Critical Subacute Care Unit, Medicine Geriatric-Rehabilitation Department, and Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy

[3] Department of Internistic Ultrasound, “G. d’Annunzio” University of Chieti and Pescara, Chieti, Italy

[4] Department of Clinical Sciences, Lund University, Malmö, Sweden

关键词: Cardiovascular;    gastroenterology/hepatology;    NAFLD;    cardiovascular disease;    cardiovascular risk;   

DOI  :  10.1177/2050312120933804

 received in 2019-10-28, accepted in 2020-05-21,  发布年份 2020

来源: Sage Journals

【 摘 要 】

Nonalcoholic fatty liver disease is increasingly recognized as a major global health problem. Intertwined with diabetes, metabolic syndrome, and obesity, nonalcoholic fatty liver disease embraces a spectrum of liver conditions spanning from steatosis to inflammation, fibrosis, and liver failure. Compared with the general population, the prevalence of cardiovascular disease is higher among nonalcoholic fatty liver disease patients, in whom comprehensive cardiovascular risk assessment is highly desirable. Preclinical effects of nonalcoholic fatty liver disease on the heart include both metabolic and structural changes eventually preceding overt myocardial dysfunction. Particularly, nonalcoholic fatty liver disease is associated with enhanced atherosclerosis, heart muscle disease, valvular heart disease, and arrhythmias, with endothelial dysfunction, inflammation, metabolic dysregulation, and oxidative stress playing in the background. In this topical review, we aimed to summarize current evidence on the epidemiology of nonalcoholic fatty liver disease, discuss the pathophysiological links between nonalcoholic fatty liver disease and cardiovascular disease, illustrate nonalcoholic fatty liver disease–related cardiovascular phenotypes, and finally provide a glimpse on the relationship between nonalcoholic fatty liver disease and cardiac steatosis, mitochondrial (dys)function, and cardiovascular autonomic dysfunction.

【 授权许可】

CC BY-NC   
© The Author(s) 2020

【 图 表 】

FIGURE 22