Characterization of a hyper-viscoelastic phantom mimicking biological soft tissue using an abdominal pneumatic driver with magnetic resonance elastography (MRE)

JOURNAL OF BIOMECHANICS

卷:45

Article

Foucart, Felix²  Robert, Ludovic³  Pelletier, Kay M.⁴  Charleux, Fabrice³  Ehman, Richard⁴  Bensamoun, Sabine F.¹ 

[1] Univ Technol Compiegne, Ctr Rech Royallieu, CNRS, Lab BioMecan & BioIngn,UMR 7338, F-60206 Compiegne, France

[2] Univ Technol Compiegne, CNRS, UMR 6253, Lab Roberval, F-60206 Compiegne, France

[3] ACRIM Polyclin St Come, Compiegne, France

[4] Mayo Clin, Coll Med, Dept Radiol, Rochester, MN USA

关键词: Multifrequency magnetic resonance;    elastography;    Viscoelasticity;    Hyperelasticity;    Phantom;    Abdominal pneumatic driver;   

DOI  :  10.1016/j.jbiomech.2012.01.017

来源: Elsevier

【 摘 要 】

The purpose of this study was to create a polymer phantom mimicking the mechanical properties of soft tissues using experimental tests and rheological models. Multifrequency Magnetic Resonance Elastography (MMRE) tests were performed on the present phantom with a pneumatic driver to characterize the viscoelastic (mu, eta) properties using Voigt, Maxwell, Zener and Springpot models. To optimize the MMRE protocol, the driver behavior was analyzed with a vibrometer. Moreover, the hyperelastic properties of the phantom were determined using compressive tests and Mooney-Rivlin model. The range of frequency to be used with the round driver was found between 60 Hz and 100 Hz as it exhibits one type of vibration mode for the membrane. MRE analysis revealed an increase in the shear modulus with frequency reflecting the viscoelastic properties of the phantom showing similar characteristic of soft tissues. Rheological results demonstrated that Springpot model better revealed the viscoelastic properties (mu = 3.45 kPa, eta = 6.17 Pas) of the phantom and the Mooney-Rivlin coefficients were C-10 =1.09.10(-2) MPa and C-01 = -8.96.10(-3) MPa corresponding to mu = 3.95 kPa. These studies suggest that the phantom, mimicking soft tissue, could be used for preliminary MRE tests to identify the optimal parameters necessary for in vivo investigations. Further developments of the phantom may allow clinicians to more accurately mimic healthy and pathological soft tissues using MRE. (c) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

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