Mechanical characterisation of human ascending aorta dissection

JOURNAL OF BIOMECHANICS

卷:94

Article

Deplano, Valerie¹  Boufi, Mourad^1,2  Gariboldi, Vlad³  Loundou, Anderson D.⁴  D'Journo, Xavier Benoit⁵  Cautela, Jennifer⁶  Djemli, Amina⁷  Alimi, Yves S.² 

[1] Aix Marseille Univ, CNRS, IRPHE, Ecole Cent Marseille, Marseille, France

[2] Aix Marseille Univ, APHM, IFSTTAR, LBA,North Hosp,Dept Vasc Surg, Marseille, France

[3] Aix Marseille Univ, APHM, Timone Hosp, Dept Cardiac Surg, Marseille, France

[4] Aix Marseille Univ, SPMC EA3279, Dept Publ Hlth, Marseille, France

[5] Aix Marseille Univ, APHM, North Hosp, Dept Thorac Surg, Marseille, France

[6] Aix Marseille Univ, APHM, North Hosp, Dept Cardiol, Marseille, France

[7] Aix Marseille Univ, APHM, North Hosp, Dept Pathol, Marseille, France

关键词: Human ascending aorta;    Acute type A dissection;    Biaxial tensile test;    In vivo measurements;    Histological analysis;   

DOI  :  10.1016/j.jbiomech.2019.07.028

来源: Elsevier

【 摘 要 】

Mechanical characteristics of both the healthy ascending aorta and acute type A aortic dissection were investigated using in vitro biaxial tensile tests, in vivo measurements via transoesophageal echocardiography and histological characterisations. This combination of analysis at tissular, structural and microstructural levels highlighted the following: (i) a linear mechanical response for the dissected intimomedial flap and, conversely, nonlinear behaviour for both healthy and dissected ascending aorta; all showed anisotropy; (ii) a stiffer mechanical response in the longitudinal than in the circumferential direction for the healthy ascending aorta, consistent with the histological quantification of collagen and elastin fibre density; (iii) a link between dissection and ascending aorta stiffening, as revealed by biaxial tensile tests. This result was corroborated by in vivo measurements with stiffness index, beta, and Peterson modulus, E-p, higher for patients with dissection than for control patients. It was consistent with histological analysis on dissected samples showing elastin fibre dislocations, reduced elastin density and increased collagen density. To our knowledge, this is the first study to report biaxial tensile tests on the dissected intimomedial flap and in vivo stiffness measurements of acute type A dissection in humans. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

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