Microstructure aware modeling of biochemical transport in arterial blood clots

JOURNAL OF BIOMECHANICS

卷:127

Article

Teeraratkul, Chayut¹  Mukherjee, Debanjan¹ 

[1] Univ Colorado, Paul M Rady Dept Mech Engn, Boulder, CO 80309 USA

关键词: Thrombus;    Hemodynamics;    Transport;    Microstructure;    Thrombolysis;   

DOI  :  10.1016/j.jbiomech.2021.110692

来源: Elsevier

【 摘 要 】

Flow-mediated transport of biochemical species is central to thrombotic phenomena. Comprehensive three-dimensional modeling of flow-mediated transport around realistic macroscale thrombi poses challenges owing to their arbitrary heterogeneous microstructure. Here, we develop a microstructure aware model for species transport within and around a macroscale thrombus by devising a custom preconditioned fictitious domain formulation for thrombus-hemodynamics interactions, and coupling it with a fictitious domain advection- diffusion formulation for transport. Microstructural heterogeneities are accounted through a hybrid discrete particle-continuum approach for the thrombus interior. We present systematic numerical investigations on unsteady arterial flow within and around a three-dimensional macroscale thrombus; demonstrate the formation of coherent flow structures around the thrombus which organize advective transport; illustrate the role of the permeation processes at the thrombus boundary and subsequent intra-thrombus transport; and characterize species transport from bulk flow to the thrombus boundary and vice versa.

【 授权许可】

Free