Artery buckling analysis using a four-fiber wall model

JOURNAL OF BIOMECHANICS

卷:47

Article

Liu, Qin¹  Wen, Qi⁴  Mottahedi, Mohammad¹  Han, Hai-Chao^1,2,3 

[1] Univ Texas San Antonio, Dept Mech Engn, San Antonio, TX 78249 USA

[2] UTSA UTHSCSA, Biomed Engn Program, San Antonio, TX USA

[3] Shanghai Jiao Tong Univ, Inst Mechanobiol & Med Engn, Shanghai 200030, Peoples R China

[4] Shaanxi Prov Peoples Second Hosp, Dept Orthopaed, Xian, Peoples R China

关键词: Mechanical instability;    Critical buckling pressure;    Artery buckling;    Fiber model;    Artery wall;    Extracellular matrix;    Elastin;    Collagen;   

DOI  :  10.1016/j.jbiomech.2014.06.005

来源: Elsevier

【 摘 要 】

Artery bent buckling has been suggested as a possible mechanism that leads to artery tortuosity, which is associated with aging, hypertension, atherosclerosis, and other pathological conditions. It is necessary to understand the relationship between microscopic wall structural changes and macroscopic artery buckling behavior. To this end, the objectives of this study were to develop arterial buckling equations using a microstructure-based 4-fiber reinforced wall model, and to simulate the effects of vessel wall microstructural changes on artery buckling. Our results showed that the critical pressure increased nonlinearly with the axial stretch ratio, and the 4-fiber model predicted higher critical buckling pressures than what the Fung model predicted. The buckling equation using the 4-fiber model captured the experimentally observed reduction of critical pressure induced by elastin degradation and collagen fiber orientation changes in the arterial wall. These results improve our understanding of arterial stability and its relationship to microscopic wall remodeling, and the model provides a useful tool for further studies. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free