Prediction of trabecular bone principal structural orientation using quantitative ultrasound scanning

JOURNAL OF BIOMECHANICS

卷:45

Article

Lin, Liangjun¹  Cheng, Jiqi¹  Lin, Wei¹  Qin, Yi-Xian¹ 

[1] SUNY Stony Brook, Dept Biomed Engn, Orthopaed Bioengn Res Lab, Stony Brook, NY 11794 USA

关键词: Quantitative ultrasound;    Non-invasive measurement;    Anisotropic structure;    Trabecular bone;    Ultrasound attenuation;    Fast wave velocity;   

DOI  :  10.1016/j.jbiomech.2012.04.022

来源: Elsevier

【 摘 要 】

Bone has the ability to adapt its structure in response to the mechanical environment as defined as Wolff's Law. The alignment of trabecular structure is intended to adapt to the particular mechanical milieu applied to it. Due to the absence of normal mechanical loading, it will be extremely important to assess the anisotropic deterioration of bone during the extreme conditions, i.e., long term space mission and disease orientated disuse, to predict risk of fractures. The propagation of ultrasound wave in trabecular bone is substantially influenced by the anisotropy of the trabecular structure. Previous studies have shown that both ultrasound velocity and amplitude is dependent on the incident angle of the ultrasound signal into the bone sample. In this work, seven bovine trabecular bone balls were used for rotational ultrasound measurement around three anatomical axes to elucidate the ability of ultrasound to identify trabecular orientation. Both ultrasound attenuation (ATT) and fast wave velocity (UV) were used to calculate the principal orientation of the trabecular bone. By comparing to the mean intercept length (MIL) tensor obtained from mu CT, the angle difference of the prediction by UV was 4.45 degrees, while it resulted in 11.67 degrees angle difference between direction predicted by mu CT and the prediction by ATT. This result demonstrates the ability of ultrasound as a non-invasive measurement tool for the principal structural orientation of the trabecular bone. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

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