New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model

JOURNAL OF BIOMECHANICS

卷:44

Article

Eneyoldsen, M. S.¹  Henneberg, K. -A.¹  Jensen, J. A.¹  Lonn, L.²  Humphrey, J. D.³ 

[1] Tech Univ Denmark, Dept Elect Engn, DK-2800 Lyngby, Denmark

[2] Univ Copenhagen, Rigshosp, Dept Radiol, DK-2100 Copenhagen, Denmark

[3] Yale Univ, Dept Biomed Engn, New Haven, CT USA

关键词: Elastin;    Collagen;    Anisotropy;    Stress;    Biomechanics;   

DOI  :  10.1016/j.jbiomech.2011.01.032

来源: Elsevier

【 摘 要 】

Cigarette smoking is the leading self-inflicted risk factor for cardiovascular diseases: it causes arterial stiffening with serious sequelea including atherosclerosis and abdominal aortic aneurysms. This work presents a new interpretation of arterial stiffening caused by smoking based on data published for rat pulmonary arteries. A structurally motivated four fiber family constitutive relation was used to fit the available biaxial data and associated best-fit values of material parameters were estimated using multivariate nonlinear regression. Results suggested that arterial stiffening caused by smoking was reflected by consistent increase in an elastin-associated parameter and moreover by marked increase in the collagen-associated parameters. That is, we suggest that arterial stiffening due to cigarette smoking appears to be isotropic, which may allow simpler phenomenological models to capture these effects using a single stiffening parameter similar to the approach in isotropic continuum damage mechanics. There is a pressing need, however, for more detailed histological information coupled with more complete biaxial mechanical data for a broader range of systemic arteries. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free