Bioinjection treatment: Effects of post-injection residual stress on left ventricular wall stress

JOURNAL OF BIOMECHANICS

卷:47

Article

Lee, Lik Chuan¹  Wall, Samuel T.⁵  Genet, Martin^2,3,4  Hinson, Andy⁶  Guccione, Julius M.^2,3,4 

[1] Michigan State Univ, Dept Mech Engn, E Lansing, MI 48824 USA

[2] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Bioengn, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[5] Simula Res Lab, Oslo, Norway

[6] Lonestar Heart Inc, Oslo, Norway

关键词: Congestive heart failure;    Biomaterial injection;    Left ventricular wall stress;    Mathematical modeling;    Magnetic resonance imaging;   

DOI  :  10.1016/j.jbiomech.2014.06.026

来源: Elsevier

【 摘 要 】

Injection of biomaterials into diseased myocardium has been associated with decreased myofiber stress, restored left ventricular (LV) geometry and improved LV function. However, its exact mechanism(s) of action remained unclear. In this work, we present the first patient-specific computational model of biomaterial injection that accounts for the possibility of residual strain and stress introduced by this treatment. We show that the presence of residual stress can create more heterogeneous regional myofiber stress and strain fields. Our simulation results show that the treatment generates low stress and stretch areas between injection sites, and high. stress and stretch areas between the injections and both the endocardium and epicardium. Globally, these local changes are translated into an increase in average myofiber stress and its standard deviation (from 6.9 +/- 4.6 to 11.2 +/- 48.8 kPa and 30 +/- 15 to 35.1 +/- 50.9 kPa at end-diastole and end-systole, respectively). We also show that the myofiber stress field is sensitive to the void-to-size ratio. For a constant void size, the myofiber stress field became less heterogeneous with decreasing injection volume. These results suggest that the residual stress and strain possibly generated by biomaterial injection treatment can have large effects on the regional myocardial stress and strain fields, which may be important in the remodeling process. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free