Hemodynamic characterization of geometric cerebral aneurysm templates

JOURNAL OF BIOMECHANICS

卷:49

Article; Proceedings Paper

Nair, Priya¹  Chong, Brian W.^1,2  Indahlastari, Aprinda¹  Lindsay, James¹  DeJeu, David¹  Parthasarathy, Varsha¹  Ryan, Justin¹  Babiker, Haithem³  Workman, Christopher¹  Gonzalez, L. Fernando⁴  Frakes, David^1,5 

[1] Arizona State Univ, Sch Biol & Hlth Syst Engn, 501 E Tyler Mall,BLDG ECG RM 334, Tempe, AZ 85287 USA

[2] Mayo Clin Hosp, Phoenix, AZ USA

[3] Endovantage, Scottsdale, AZ USA

[4] Duke Univ, Sch Med, Dept Neurosurg, Durham, NC USA

[5] Arizona State Univ, Sch Elect Comp & Energy Engn, Tempe, AZ USA

关键词: Cerebral aneurysm;    Geometric template;    Hemodynamics;    Computational fluid dynamics;    Particle image velocimetry;   

DOI  :  10.1016/j.jbiomech.2015.11.034

来源: Elsevier

【 摘 要 】

Hemodynamics are currently considered to a lesser degree than geometry in clinical practices for evaluating cerebral aneurysm (CA) risk and planning CA treatment. This study establishes fundamental relationships between three clinically recognized CA geometric factors and four clinically relevant hemodynamic responses. The goal of the study is to develop a more combined geometric/hemodynamic basis for informing clinical decisions. Flows within eight idealized template geometries were simulated using computational fluid dynamics and measured using particle image velocimetry under both steady and pulsatile flow conditions. The geometric factor main effects were then analyzed to quantify contributions made by the geometric factors (aneurysmal dome size (DS), dome-to-neck ratio (DNR), and parent-vessel contact angle (PV-CA)) to effects on the hemodynamic responses (aneurysmal and neck plane root-mean-square velocity magnitude (V-rms), aneurysmal wall shear stress (WSS), and cross-neck flow (CNF)). Two anatomical aneurysm models were also examined to investigate how well the idealized findings would translate to more realistic CA geometries. DNR made the greatest contributions to effects on hemodynamics including a 75.05% contribution to aneurysmal V-rms and greater than 35% contributions to all responses. DS made the next greatest contributions, including a 43.94% contribution to CNF and greater than 20% contributions to all responses. PV-CA and several factor interactions also made contributions of greater than 10%. The anatomical aneurysm models and the most similar idealized templates demonstrated consistent hemodynamic response patterns. This study demonstrates how individual geometric factors, and combinations thereof, influence CA hemodynamics. Bridging the gap between geometry and flow in this quantitative yet practical way may have potential to improve CA evaluation and treatment criteria. Agreement among results from idealized and anatomical models further supports the potential for a template-based approach to play a useful role in clinical practice. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free