Improved measurement of brain deformation during mild head acceleration using a novel tagged MRI sequence

JOURNAL OF BIOMECHANICS

卷:47

Article

Knutsen, Andrew K.¹  Magrath, Elizabeth¹  McEntee, Julie E.¹  Xing, Fangxu²  Prince, Jerry L.^2,3  Bayly, Philip V.^4,5  Butman, John A.^1,6  Pham, Dzung L.¹ 

[1] Henry M Jackson Fdn, Ctr Neurosci & Regenerat Med, Bethesda, MD 20892 USA

[2] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA

[4] Dept Mech Engn & Mat Sci, St Louis, MO USA

[5] Washington Univ, Dept Biomed Engn, St Louis, MO USA

[6] NIH, Dept Diagnost Radiol, Ctr Clin, Bethesda, MD 20892 USA

关键词: Magnetic resonance imaging (MRD);    Acceleration;    Deformation;    Strain;    Traumatic brain injury (TBI);   

DOI  :  10.1016/j.jbiomech.2014.09.010

来源: Elsevier

【 摘 要 】

In vivo measurements of human brain deformation during mild acceleration are needed to help validate computational models of traumatic brain injury and to understand the factors that govern the mechanical response of the brain. Tagged magnetic resonance imaging is a powerful, noninvasive technique to track tissue motion in vivo which has been used to quantify brain deformation in live human subjects. However, these prior studies required from 72 to 144 head rotations to generate deformation data for a single image slice, precluding its use to investigate the entire brain in a single subject. Here, a novel method is introduced that significantly reduces temporal variability in the acquisition and improves the accuracy of displacement estimates. Optimization of the acquisition parameters in a gelatin phantom and three human subjects leads to a reduction in the number of rotations from 72 to 144 to as few as 8 for a single image slice. The ability to estimate accurate, well-resolved, fields of displacement and strain in far fewer repetitions will enable comprehensive studies of acceleration-induced deformation throughout the human brain in vivo. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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