Valveless pumping mechanics of the embryonic heart during cardiac looping: Pressure and flow through micro-PIV

JOURNAL OF BIOMECHANICS

卷:50

Article; Proceedings Paper

Bark, D. L., Jr.^1,2  Johnson, B.^1,2  Garrity, D.³  Dasi, L. P.^1,2,4 

[1] Colorado State Univ, Dept Mech Engn, 1374 Campus Delivery, Ft Collins, CO 80523 USA

[2] Colorado State Univ, Sch Biomed Engn, Ft Collins, CO 80523 USA

[3] Colorado State Univ, Dept Biol, 1878 Campus Delivery,Ft Collins, Ft Collins, CO 80523 USA

[4] Ohio State Univ, DHLRI, Dept Biomed Engn & Surg, 473 W 12th Ave, Columbus, OH 43210 USA

关键词: Heart;    Zebrafish;    Blood flow;    Pressure;    Development;   

DOI  :  10.1016/j.jbiomech.2016.11.036

来源: Elsevier

【 摘 要 】

Cardiovascular development is influenced by the flow-induced stress environment originating from cardiac biomechanics. To characterize the stress environment, it is necessary to quantify flow and pressure. Here, we quantify the flow field in a developing zebrafish heart during the looping stage through micro-particle imaging velocimetry and by analyzing spatiotemporal plots. We further build upon previous methods to noninvasively quantify the pressure field at a low Reynolds number using flow field data for the first time, while also comparing the impact of viscosity models. Through this method, we show that the atrium builds up pressure to 0.25 mmHg relative to the ventricle during atrial systole and that atrial expansion creates a pressure difference of 0.15 mmHg across the atrium, resulting in efficient cardiac pumping. With these techniques, it is possible to noninvasively fully characterize hemodynamics during heart development. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free