Computational assessment of hemodynamics-based diagnostic tools using a database of virtual subjects: Application to three case studies

JOURNAL OF BIOMECHANICS

卷:49

Article

Willemet, Marie¹  Vennin, Samuel^1,2  Alastruey, Jordi¹ 

[1] St Thomas Hosp, Kings Coll London, Div Imaging Sci & Biomed Engn, London, England

[2] St Thomas Hosp, British Heart Fdn Ctr, Kings Coll London, Dept Clin Pharmacol, London, England

关键词: Arterial hemodynamics;    1D modelling;    Pulse wave velocity;    Central pressure;    Aortic flow;    Augmentation index;   

DOI  :  10.1016/j.jbiomech.2016.11.001

来源: Elsevier

【 摘 要 】

Many physiological indexes and algorithms based on pulse wave analysis have been suggested in order to better assess cardiovascular function. Because these tools are often computed from in-vivo hemodynamic measurements, their validation is time-consuming, challenging, and biased by measurement errors. Recently, a new methodology has been suggested to assess theoretically these computed tools: a database of virtual subjects generated using numerical 1D-OD modeling of arterial hemodynamics. The generated set of simulations encloses a wide selection of healthy cases that could be encountered in a clinical study. We applied this new methodology to three different case studies that demonstrate the potential of our new tool, and illustrated each of them with a clinically relevant example: (i) we assessed the accuracy of indexes estimating pulse wave velocity; (ii) we validated and refined an algorithm that computes central blood pressure; and (iii) we investigated theoretical mechanisms behind the augmentation index. Our database of virtual subjects is a new tool to assist the clinician: it provides insight into the physical mechanisms underlying the correlations observed in clinical practice. (C) 2016 The Authors. Published by Elsevier Ltd.

【 授权许可】

Free