A clinical perspective on endovascular stroke treatment biomechanics

JOURNAL OF BIOMECHANICS

卷:127

Article

Ospel, Johanna M.^1,2,5  van der Lugt, Aad³  Gounis, Matthew⁴  Goyal, Mayank^1,5  Majoie, Charles B. L. M.⁶ 

[1] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada

[2] Univ Hosp Basel, Dept Neuroradiol, Basel, Switzerland

[3] Erasmus MC Univ Med Ctr, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[4] Univ Massachusetts, Sch Med, Dept Radiol, Worcester, MA USA

[5] Univ Calgary, Dept Diagnost Imaging, Calgary, AB, Canada

[6] Univ Amsterdam, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands

关键词: Clot;    Thrombus;    Stroke biomechanics;   

DOI  :  10.1016/j.jbiomech.2021.110694

来源: Elsevier

【 摘 要 】

Acute ischemic stroke (AIS) is caused by blockage of an arterial blood vessel in the brain by a thrombus, which interrupts oxygen supply to the brain parenchyma. The goal of endovascular stroke treatment (mechanical thrombectomy) is to restore blood flow as quickly and completely as possible. There are numerous factors that influence endovascular treatment success. They can be broadly grouped into a) factors related to blood vessels, b) factors related to the thrombus, c) factors related to endovascular treatment technique and tools and d) operatorrelated factors. While blood vessel and tgthro thrombus-related factors are mostly non-modifiable in the acute setting, operator and technique-related factors can be modified, and extensive research is currently being done to investigate the complex interplay of all these variables, and to optimize the modifiable factors to the maximum possible extent. In this review, we will describe these factors and how they interact with each other in detail, and outline some of their practical implications. We will conclude with a short summary and outlook on future directions for optimizing endovascular treatment success.

【 授权许可】

Free