Patient-specific computational evaluation of stiffness distribution in ascending thoracic aortic aneurysm

JOURNAL OF BIOMECHANICS

卷:119

Article

Di Giuseppe, Marzio¹  Farzaneh, Solmaz²  Zingales, Massimiliano³  Pasta, Salvatore³  Avril, Stephane² 

[1] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, I-90128 Palermo, Italy

[2] Univ Lyon, Univ Jean Monnet, U1059 SAINBIOSE, INSERM,Mines St Etienne, F-42023 St Etienne, France

[3] Univ Palermo, Dept Engn, Viale Sci,Ed 8, I-90128 Palermo, Italy

关键词: Ascending thoracic aortic aneurysm;    Bicuspid aortic valve;    Extensional stiffness;    Noninvasive inverse method;    Shear stress;   

DOI  :  10.1016/j.jbiomech.2021.110321

来源: Elsevier

【 摘 要 】

Quantifying local aortic stiffness properties in vivo is acknowledged as essential to assess the severity of an ascending thoracic aortic aneurysm (ATAA). Recently, the LESI (local extensional stiffness identification) methodology has been established to quantify non-invasively local stiffness properties of ATAAs using electrocardiographic-gated computed tomography (ECG-gated CT) scans. The aim of the current study was to determine the most sensitive markers of local ATAA stiffness estimation with the hypothesis that direct measures of local ATAA stiffness could better detect the high-risk patients. A cohort of 30 patients (12 BAV and 18 TAV) referred for aortic size evaluation by ECG-gated CT were recruited. For each patient, the extensional stiffness Q was evaluated by the LESI methodology whilst computational flow analyses were also performed to derive hemodynamics markers such as the wall shear stress (WSS). A strong positive correlation was found between the extensional stiffness and the aortic pulse pressure (R = 0.644 and p < 0.001). Interestingly, a significant positive correlation was also found between the extensional stiffness and patients age for BAV ATAAs (R = 0.619 and p = 0.032), but not for TAV ATAAs (R =-0.117 and p = 0.645). No significant correlation was found between the extensional stiffness and WSS evaluated locally. There was no significant difference either in the extensional stiffness between BAV ATAAs and TAV ATAAs (Q = 3.6 +/- 2.5 MPa.mm for BAV ATAAs vs Q = 5.3 +/- 3.1 MPa.mm for TAV ATAAs, p = 0.094). Future work will focus on relating the extensional stiffness to the patient-specific rupture risk of ATAAs on larger cohorts to confirm the promising interest of the LESI methodology. (c) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

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