Older asymptomatic women exhibit patterns of thumb carpometacarpal joint space narrowing that precede changes associated with early osteoarthritis

JOURNAL OF BIOMECHANICS

卷:48

Article

Halilaj, Eni^1,2  Moore, Douglas C.^3,4  Patel, Tarpit K.^3,4  Laidlaw, David H.⁵  Ladd, Amy L.⁶  Weiss, Arnold-Peter C.^3,4  Crisco, Joseph J.^1,2,3,4 

[1] Brown Univ, Ctr Biomed Engn, Providence, RI 02912 USA

[2] Brown Univ, Sch Engn, Providence, RI 02912 USA

[3] Brown Univ, Warren Alpert Med Sch, Dept Orthopaed, Providence, RI 02903 USA

[4] Rhode Isl Hosp, Providence, RI 02903 USA

[5] Brown Univ, Dept Comp Sci, Providence, RI 02912 USA

[6] Stanford Univ, Dept Orthopaed Surg, Robert A Chase Hand & Upper Limb Ctr, Stanford, CA 94304 USA

关键词: Thumb CMC;    Cartilage;    Joint space;    Osteoarthritis;    Joint biomechanics;    Computed tomography;    In vivo;   

DOI  :  10.1016/j.jbiomech.2015.08.010

来源: Elsevier

【 摘 要 】

In small joints, where cartilage is difficult to image and quantify directly, three-dimensional joint space measures can be used to gain insight into potential joint pathomechanics. Since the female sex and older age are risk factors for carpometacarpal (CMC) joint osteoarthritis (OA), the purpose of this in vivo computed tomography (CT) study was to determine if there are any differences with sex, age, and early OA in the CMC joint space. The thumbs of 66 healthy subjects and 81 patients with early stage CMC OA were scanned in four range-of-motion, three functional-task, and one neutral positions. Subchondral bone-to-bone distances across the trapezial and metacarpal articular surfaces were computed for all the positions. The joint space area, defined as the articular surface that is less than 1.5 mm from the mating bone, was used to assess joint space. A larger joint space area typically corresponds to closer articular surfaces, and therefore a narrower joint space. We found that the joint space areas are not significantly different between healthy young men and women. Trends indicated that patients with early stage OA have larger CMC joint space areas than healthy subjects of the same age group and that older healthy women have larger joint space areas than younger healthy women. This study suggests that aging in women may lead to joint space narrowing patterns that precede early OA, which is a compelling new insight into the pathological processes that make CMC OA endemic to women. (C) 2015 Elsevier Ltd. All rights reserved.

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