Musculoskeletal full-body models including a detailed thoracolumbar spine for children and adolescents aged 6-18 years

JOURNAL OF BIOMECHANICS

卷:102

Article; Proceedings Paper

Schmid, Stefan^1,2,3  Burkhart, Katelyn A.^1,4  Allaire, Brett T.¹  Grindle, Daniel¹  Anderson, Dennis E.^1,2 

[1] Beth Israel Deaconess Med Ctr, Ctr Adv Orthopaed Studies, Boston, MA 02215 USA

[2] Harvard Med Sch, Dept Orthopaed Surg, Boston, MA 02115 USA

[3] Bern Univ Appl Sci, Dept Hlth Profess, Div Physiotherapy, Bern, Switzerland

[4] MIT, Harvard Mit Hlth Sci & Technol Program, 77 Massachusetts Ave, Cambridge, MA 02139 USA

关键词: OpenSim;    Modeling;    Development;    Validation;    Static optimization;   

DOI  :  10.1016/j.jbiomech.2019.07.049

来源: Elsevier

【 摘 要 】

Currently available musculoskeletal inverse-dynamics thoracolumbar spine models are entirely based on data from adults and might therefore not be applicable for simulations in children and adolescents. In addition, these models lack lower extremities, which are required for comprehensive evaluations of functional activities or therapeutic exercises. We therefore created OpenSim-based musculoskeletal full-body models including a detailed thoracolumbar spine for children and adolescents aged 6-18 years and validated by comparing model predictions to in vivo data. After combining our recently developed adult thoracolumbar spine model with a lower extremity model, children and adolescent models were created for each year of age by adjusting segmental length and mass distribution, center of mass positions and moments of inertia of the major body segments as well as sagittal pelvis and spine alignment based on literature data. Similarly, muscle strength properties were adjusted based on CT-derived cross-sectional area measurements. Simulations were conducted from in vivo studies reported in the literature involving children and adolescents evaluating maximum trunk muscle strength (MTMS), lumbar disc compressibility (LDC), intradiscal pressure (IDP) and trunk muscle activity (MA). Model predictions correlated highly with in vivo data (MTMS: r >= 0.82, p <= 0.03; LDC: r = 0.77, p < 0.001; IDP: r >= 0.78, p < 0.001; MA: r >= 0.90, p < 0.001), indicating suitability for the reasonably accurate prediction of maximal trunk muscle strength, segmental loading and trunk muscle activity in children and adolescents. When aiming at investigating children or adolescents with pathologies such as idiopathic scoliosis, our models can serve as a basis for the creation of deformed spine models and for comparative purposes. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free