Mechanical profiling of intervertebral discs

JOURNAL OF BIOMECHANICS

卷:42

Article

Schultz, David S.^1,2  Rodriguez, Azucena G.¹  Hansma, Paul K.³  Lotz, Jeffrey C.¹ 

[1] Univ Calif San Francisco, Dept Orthopaed Surg, San Francisco, CA 94143 USA

[2] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA

[3] Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA

关键词: Intervertebral disc;    MRI;    Annulus fibrosus;    Nucleus pulposus;    Mechanical properties;    Degeneration;   

DOI  :  10.1016/j.jbiomech.2009.02.013

来源: Elsevier

【 摘 要 】

Despite recent advances in imaging diagnostic technology and additional treatment options our ability to prevent or inhibit discogenic back pain has not drastically improved. The challenge of linking early degenerative patterns to dysfunction and pain remains. Using a novel material testing device designated the tissue diagnostic instrument (TDI) we measured the local stiffness and strain energy absorption in the radial direction of 13 intact intervertebral discs: effectively generating a mechanical profile of each disc. Prior to measuring mechanical properties, an MR image was taken of each spine segment and the discs were radiologically scored according to the Pfirrmann scale. After testing, a sagittal portion of each L1-L2 disc was excised from each of four spines for histology. No significant correlations were found between Pfirrmann grade and mechanical data. However, polarized light microscopy images of disc sections indicated correlations between local tissue modulus measured with the TDI and the clarity and density of lamellar striations. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

Free