Elastic properties of organ of Corti tissues from point-stiffness measurement and inverse analysis

JOURNAL OF BIOMECHANICS

卷:47

Article

Zagadou, B. F.^1,2  Barbone, P. E.³  Mountain, D. C.^1,2 

[1] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[2] Boston Univ, Hearing Res Ctr, Boston, MA 02215 USA

[3] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA

关键词: Gerbil;    Cochlea;    Finite element;    Sensitivity analysis;    Bayesian perspective;   

DOI  :  10.1016/j.jbiomech.2014.02.025

来源: Elsevier

【 摘 要 】

We describe a method to use point-stiffness (PtSt) measurements, i.e., indentation measurements, to obtain elastic moduli of different organ of Corti (OC) tissues. A detailed finite element (FE) model of the OC is used to account for geometric effects in the indentation measurements. We also present a sensitivity analysis, performed within a Bayesian estimation framework, that can be used to improve experimental design. The sensitivity analysis shows that the basilar membrane (BM) PtSt is most sensitive to changes in the BM properties and to changes in the pillar cells (PC) properties. This result suggests that the BM and the PC dominate the macromechanics of the DC. The most likely values of the Young's modulus predicted for the middle turn for the BM arcuate, BM pectinate, and the PC are found to be 935 KPa (range 640-1360 KPa), 300 KPa (range 190-460 KPa), and 3 GPa (range 1-9 GPa), respectively. (c) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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