Effects of vessel compliance on flow pattern in porcine epicardial right coronary arterial tree

JOURNAL OF BIOMECHANICS

卷:42

Article

Huo, Yunlong¹  Choy, Jenny Susana¹  Svendsen, Mark²  Sinha, Anjan Kumar³  Kassab, Ghassan S.¹ 

[1] IUPUL, Dept Biomed Engn Surg & Cellular & Integrat Physi, Indianapolis, IN 46202 USA

[2] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA

[3] IUPUL, Dept Med, Indianapolis, IN 46202 USA

关键词: Vessel compliance;    Atherosclerosis;    Wall shear stress;    Finite element;   

DOI  :  10.1016/j.jbiomech.2008.12.011

来源: Elsevier

【 摘 要 】

The compliance of the vessel wall affects hemodynamic parameters which may alter the permeability of the vessel wall. Based on experimental measurements, the present study established a finite element (FE) model in the proximal elastic vessel segments of epicardial right coronary arterial (RCA) tree obtained from computed tomography. the motion of elastic vessel wall was measured by an impedance catheter and the inlet boundary condition was measured by an ultrasound flow probe. The Galerkin FE method was used to solve the Navier-Stokes and Continuity equations, where the convective term in the Navier-Stokes equation was changed in the arbitrary Lagrangian-Eulerian (ALE) framework to incorporate the motion due to vessel compliance. Various hemodynamic parameters (e.g., wall shear stress WSS, WSS spatial gradient WSSG, oscillatory shear index-OSI) were analyzed in the model. The motion due to vessel compliance affects the time-averaged WSSG more strongly then WSS at bifurcations. The decrease of WSSG at flow divider in elastic bifurcations, as compared to rigid bifurcations, implies that the vessel compliance decreases the permeability of vessel wall and may be atheroprotective. the model can be used to predict coronary flow pattern in subject-specific anatomy as determined by noninvasive imaging. Published by Elsevier Ltd.

【 授权许可】

Free