An efficient full space-time discretization method for subject-specific hemodynamic simulations of cerebral arterial blood flow with distensible wall mechanics

JOURNAL OF BIOMECHANICS

卷:87

Article

Park, Chang Sub¹  Alaraj, Ali²  Du, Xinjian²  Charbel, Fady T.²  Linninger, Andreas A.^1,2 

[1] Univ Illinois, Dept Bioengn, 851 S Morgan St 218 SEO, Chicago, IL 60607 USA

[2] Univ Illinois, Dept Neurosurg, Chicago, IL USA

关键词: One-dimensional blood flow;    Fluid-structure interaction;    Cerebral arterial tree;    Quantitative magnetic resonance angiography;    Pulsatile flow;   

DOI  :  10.1016/j.jbiomech.2019.02.014

来源: Elsevier

【 摘 要 】

A computationally inexpensive mathematical solution approach using orthogonal collocations for space discretization with temporal Fourier series is proposed to compute subject-specific blood flow in distensible vessels of large cerebral arterial networks. Several models of wall biomechanics were considered to assess their impact on hemodynamic predictions. Simulations were validated against in vivo blood flow measurements in six human subjects. The average root-mean-square relative differences were found to be less than 4.3% for all subjects with a linear elastic wall model. This discrepancy decreased further in a viscoelastic Kelvin-Voigt biomechanical wall. The results provide support for the use of collocation-Fourier series approach to predict clinically relevant blood flow distribution and collateral blood supply in large portions of the cerebral circulation at reasonable computational costs. It thus opens the possibility of performing computationally inexpensive subject-specific simulations that are robust and fast enough to predict clinical results in real time on the same day. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free