Influence of shear rate and surface chemistry on thrombus formation in micro-crevice

JOURNAL OF BIOMECHANICS

卷:121

Article

Zhussupbekov, Mansur¹  Wu, Wei -Tao²  Jamiolkowski, Megan A.³  Massoudi, Mehrdad⁴  Antaki, James F.¹ 

[1] Cornell Univ, Meinig Sch Biomed Engn, Weill Hall 109, Ithaca, NY 14853 USA

[2] Nanjing Univ Sci & Technol, Sch Mech Engn, Nanjing, Peoples R China

[3] US FDA, Ctr Devices & Radiol Hlth CDRH, Off Sci & Engn Labs OSEL, Silver Spring, MD USA

[4] US DOE, Natl Energy Technol Lab NETL, Pittsburgh, PA USA

关键词: Thrombosis;    Platelet deposition;    Shear cleaning;    Crevice;    Biomaterials;    Blood flow;    Numerical modeling;   

DOI  :  10.1016/j.jbiomech.2021.110397

来源: Elsevier

【 摘 要 】

Thromboembolic complications remain a central issue in management of patients on mechanical circu-latory support. Despite the best practices employed in design and manufacturing of modern ventricular assist devices, complexity and modular nature of these systems often introduces internal steps and cre-vices in the flow path which can serve as nidus for thrombus formation. Thrombotic potential is influ-enced by multiple factors including the characteristics of the flow and surface chemistry of the biomaterial. This study explored these elements in the setting of blood flow over a micro-crevice using a multi-constituent numerical model of thrombosis. The simulations reproduced the platelet deposition patterns observed experimentally and elucidated the role of flow, shear rate, and surface chemistry in shaping the deposition. The results offer insights for design and operation of blood-contacting devices. (c) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

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