Mechanotransduction and fibrosis

JOURNAL OF BIOMECHANICS

卷:47

Article

Duscher, Dominik¹  Maan, Zeshaan N.¹  Wong, Victor W.²  Rennert, Robert C.¹  Januszyk, Michael¹  Rodrigues, Melanie¹  Hu, Michael¹  Whitmore, Arnetha J.¹  Whittam, Alexander J.¹  Longaker, Michael T.¹  Gurtner, Geoffrey C.¹ 

[1] Stanford Univ, Div Plast & Reconstruct Surg, Hagey Lab Pediat Regenerat Med, Dept Surg,Sch Med, Stanford, CA 94305 USA

[2] Johns Hopkins Univ, Sch Med, Dept Plast Surg, Baltimore, MD USA

关键词: Mechanotransduction;    Mechanical signaling;    Fibrosis;    Scarring;   

DOI  :  10.1016/j.jbiomech.2014.03.031

来源: Elsevier

【 摘 要 】

Scarring and tissue fibrosis represent a significant source of morbidity in the United States. Despite considerable research focused on elucidating the mechanisms underlying cutaneous scar formation, effective clinical therapies are still in the early stages of development. A thorough understanding of the various signaling pathways involved is essential to formulate strategies to combat fibrosis and scarring. While initial efforts focused primarily on the biochemical mechanisms involved in scar formation, more recent research has revealed a central role for mechanical forces in modulating these pathways. Mechanotransduction, which refers to the mechanisms by which mechanical forces are converted to biochemical stimuli, has been closely linked to inflammation and fibrosis and is believed to play a critical role in scarring. This review provides an overview of our current understanding of the mechanisms underlying scar formation, with an emphasis on the relationship between mechanotransduction pathways and their therapeutic implications. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free