Sleep matters: Sleep functioning and course of illness in bipolar disorder

JOURNAL OF AFFECTIVE DISORDERS

卷:134

Article

Gruber, June¹  Miklowitz, David J.²  Harvey, Allison G.³  Frank, Ellen⁴  Kupfer, David⁴  Thase, Michael E.⁴  Sachs, Gary S.^5,6  Ketter, Terence A.⁷ 

[1] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

[2] Univ Calif Los Angeles, Div Child & Adolescent Psychiat, Semel Inst, Los Angeles, CA USA

[3] Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA

[4] Univ Pittsburgh, Dept Psychiat, Med Ctr, Pittsburgh, PA 15260 USA

[5] Massachusetts Gen Hosp, Bipolar Clin, Boston, MA 02114 USA

[6] Massachusetts Gen Hosp, Res Program, Boston, MA 02114 USA

[7] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

关键词: Bipolar disorder;    Sleep;    Mania;    Depression;    Functioning;    STEP-BD;   

DOI  :  10.1016/j.jad.2011.05.016

来源: Elsevier

【 摘 要 】

Background: Few studies have prospectively examined the relationships of sleep with symptoms and functioning in bipolar disorder. Methods: The present study examined concurrent and prospective associations between total sleep time (TST) and sleep variability (SV) with symptom severity and functioning in a cohort of DSM-IV bipolar patients (N = 468) participating in the National Institute of Mental Health Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), all of whom were recovered at study entry. Results: Concurrent associations at study entry indicated that shorter TST was associated with increased mania severity, and greater SV was associated with increased mania and depression severity. Mixed-effects regression modeling was used to examine prospective associations in the 196 patients for whom follow-up data were available. Consistent with findings at study entry, shorter TST was associated with increased mania severity, and greater SV was associated with increased mania and depression severity over 12 months. Discussion: These findings highlight the importance of disrupted sleep patterns in the course of bipolar illness. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

Free