Mindfulness-based intervention to decrease mood lability in at-risk youth: Preliminary evidence for changes in resting state functional connectivity

JOURNAL OF AFFECTIVE DISORDERS

卷:276

Article

Hafeman, Danella M.^1,3  Ostroff, A. Noelle²  Feldman, Jamie³  Hickey, Mary Beth³  Phillips, Mary L.¹  Creswell, David⁴  Birmaher, Boris^1,3  Goldstein, Tina R.¹ 

[1] Univ Pittsburgh, Dept Psychiat, Sch Med, 3811 OHara St, Pittsburgh, PA 15213 USA

[2] Chatham Univ, Dept Counseling Psychol, Pittsburgh, PA 15232 USA

[3] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15213 USA

[4] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA

关键词: Mindfulness;    Bipolar disorder;    Resting-state functional connectivity;    Emotion regulation;    Mood lability;    Neuroimaging;   

DOI  :  10.1016/j.jad.2020.06.042

来源: Elsevier

【 摘 要 】

Background: In youth at familial risk for bipolar disorder (BD), mood lability is an important precursor to BD onset. Previous work in adults indicates that mindfulness-based interventions (MBI) may improve emotion regulation, in part by increasing resting-state functional connectivity (rsFC) between posterior cingulate cortex (PCC) and executive control network (ECN). In this pilot study, we assessed effects of an MBI on PCC-ECN rsFC and mood lability in at-risk youth. Methods: We recruited 35 youth (10-14 years old) with a first-degree family history of BD and mood lability, and 21 age-matched healthy controls. Eligible at-risk youth were scanned pre/post an 8-week MBI and assessed three months later. Healthy controls were scanned at matched timepoints but did not participate in the MBI. The MBI used age-appropriate strategies to promote non-judgmental, present-moment awareness. We assessed pre/post changes in PCC-ECN rsFC and how rsFC changes were related to mood outcomes. Results: Twenty at-risk youth were scanned pre/post MBI; 16 had high-quality rsFC data. Following MBI, at-risk youth showed increased rsFC between PCC and left dorsolateral prefrontal cortex (DLPFC) (BA 9; k = 28; corrected p=.006); healthy controls did not show this increase. Following MBI, at-risk youth reported more mindfulness (F = 7.15, p=.003), less mood lability (F = 7.2, p=.002), and less suppression of negative emotions (F = 5.05, p=.01). PCC-DLPFC rsFC increases predicted less mood lability (t=-2.25, p=.04) and less emotion suppression (t=-2.75, p=.02) at follow-up. Limitations: Small sample and lack of a control intervention. Conclusions: PCC-DLPFC rsFC may be a clinically meaningful neural target of an MBI in at-risk youth, related to improvements in mood lability.

【 授权许可】

Free