Examining the relationship between lifetime stressful life events and the onset of major depression in Chinese women

JOURNAL OF AFFECTIVE DISORDERS

卷:135

Article

Tao, Ming²  Li, Yihan³  Xie, Dong³  Wang, Zhiyang⁴  Qiu, Jianying⁵  Wu, Wenyuan⁶  Sun, Jing⁷  Wang, Zhoubing⁸  Tao, Danhong²  Zhao, Hongsu¹  Tian, Tian⁹  Zhang, Jingxuan¹⁰  Gao, Chengge¹¹  Niu, Qihui¹²  Li, Qiang¹³  Liu, Shanming¹⁴  Liu, Jia¹⁵  Zhang, Yunshu¹⁶  He, Qiang¹⁷  Rong, Han¹⁸  Gan, Zhaoyu¹⁹  Li, Jianying²⁰  Chen, Xiansheng²¹  Pan, Jiyang²²  Li, Yi²³  Cui, Yanping²⁴  Han, Wei²⁵  Ma, Huan²⁶  Xie, Shoufu^27,28  Jin, Guixing²⁹  Li, Ling³⁰  Zhang, Ruiling³¹  Tan, Qingrong³²  Zhang, Jun³³  Guan, Jing³⁴  Shi, Shenxun^4,5  Chen, Yiping³⁵  Kendler, Kenneth S.³⁶  Flint, Jonathan³  Gao, Jingfang¹ 

[1] Zhejiang Tradit Chinese Med Hosp, Hangzhou 310006, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Affiliated Hosp 2, Hangzhou 310005, Zhejiang, Peoples R China

[3] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[4] Fudan Univ, Huashan Hosp, Shanghai 200040, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China

[6] Shanghai Tongji Univ, Tongji Hosp, Shanghai 200065, Peoples R China

[7] Nanjing Brain Hosp, Nanjing 210029, Jiangsu, Peoples R China

[8] Jiangsu Univ, Affiliated Hosp 4, Zhenjiang 212001, Jiangsu, Peoples R China

[9] Tianjin Anding Hosp, Tianjin 300222, Peoples R China

[10] Shandong Mental Hlth Ctr, Jinan 250014, Shandong, Peoples R China

[11] Xi An Jiao Tong Univ, Coll Med, Hosp 1, Xian 710061, Shaanxi, Peoples R China

[12] Zhengzhou Univ, Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[13] Harbin Med Coll, Mental Hlth Ctr 1, Harbin, Heilongjiang, Peoples R China

[14] Sichuan Univ, Mental Hlth Ctr, W China Hosp, Chengdu 610041, Sichuan, Peoples R China

[15] Capital Med Univ, Beijing Anding Hosp, Beijing 100088, Peoples R China

[16] Hebei Mental Hlth Ctr, Baoding 071000, Hebei, Peoples R China

[17] China Med Univ, Shengjing Hosp, Shenyang 110817, Liaoning, Peoples R China

[18] Shenzhen Kangning Hosp, Shenzhen 518020, Peoples R China

[19] Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China

[20] Shanxi Med Univ, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China

[21] Mental Hosp Jiangxi Prov, Nanchang 330029, Jiangxi, Peoples R China

[22] Jinan Univ, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China

[23] Wuhan Mental Hlth Ctr, Wuhan 430022, Peoples R China

[24] 3 Hosp Heilongjiang Prov, Beian, Heilongjiang, Peoples R China

[25] Jilin Brain Hosp, Siping 136000, Jilin, Peoples R China

[26] China Med Univ, Hosp 1, Shenyang 110001, Peoples R China

[27] Dalian 7 Peoples Hosp, Dalian, Peoples R China

[28] Dalian Mental Hlth Ctr, Dalian, Peoples R China

[29] Hebei Med Univ, Hosp 1, Shijiazhuang 050031, Peoples R China

[30] Lanzhou Univ, Lanzhou Univ Hosp 2, Clin Med Coll 2, Lanzhou 730030, Gansu, Peoples R China

[31] Psychiat Hosp Henan Prov, Xinxiang, Henan, Peoples R China

[32] Fourth Mil Med Univ, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China

[33] 4 Peoples Hosp Liaocheng, Liaocheng 252000, Shandong, Peoples R China

[34] Guangzhou Psychiat Hosp, Guangzhou Brain Hosp, Guangzhou 510370, Guangdong, Peoples R China

[35] Clin Trial Serv Unit, Oxford OX3 7LF, England

[36] Virginia Commonwealth Univ, Dept Psychiat, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA

关键词: Major depressive disorder;    Stressful life event;    Social adversity;    Symptom;   

DOI  :  10.1016/j.jad.2011.06.054

来源: Elsevier

【 摘 要 】

Background: In European and US studies, patients with major depressive disorder (MDD) report more stressful life events (SLEs) than controls, but this relationship has rarely been studied in Chinese populations. Methods: Sixteen lifetime SLEs were assessed at interview in two groups of Han Chinese women: 1970 clinically ascertained with recurrent MDD and 2597 matched controls. Diagnostic and other risk factor information was assessed at personal interview. Odds ratios (ORs) were calculated by logistic regression. Results: 60% of controls and 72% of cases reported at least one lifetime SLE. Fourteen of the sixteen SLEs occurred significantly more frequently in those with MDD (median odds ratio of 1.6). The three SLEs most strongly associated with risk for MDD (OR>3.0) preceded the onset of MDD the majority of the time: rape (82%), physical abuse (100%) and serious neglect (99%). Limitations: Our results may apply to females only. SLEs were rated retrospectively and are subject to biases in recollection. We did not assess contextual information for each life event. Conclusions: More severe SLEs are more strongly associated with MDD. These results support the involvement of psychosocial adversity in the etiology of MDD in China. (C) 2011 Elsevier B.V. All rights reserved.

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