Mitochondrial genetic haplogroups and depressive symptoms: A large study among people in North America

JOURNAL OF AFFECTIVE DISORDERS

卷:217

Article

Veronese, Nicola¹  Stubbs, Brendon^2,3,4,5  Solmi, Marco^2,6  Vaona, Alberto⁷  Demurtas, Jacopo⁸  Carvalho, Andre F.⁹  Koyanagi, Ai¹⁰  Thompson, Trevor¹¹  Zoratti, Mario¹²  Maggi, Stefania¹ 

[1] CNR, Neurosci Inst, Aging Branch, Via Giustiniani 2, I-35128 Padua, Italy

[2] Inst Clin Res & Educ Med IREM, Padua, Italy

[3] South London & Maudsley NHS Fdn Trust, Denmark Hill, London SE5 8AZ, England

[4] Kings Coll London, Inst Psychiat Psychol & Neurosci, De Crespigny Pk, London SE5 8AF, England

[5] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Chelmsford, England

[6] Univ Padua, Dept Neurosci, Padua, Italy

[7] Azienda ULSS20 Verona, Primary Care Dept, Verona, Italy

[8] Azienda USL Toscana Sud Est, Primary Care Dept, Grosseto, Italy

[9] Univ Fed Ceara, Fac Med, Dept Clin Med, Translat Psychiat Res Grp, Fortaleza, Ceara, Brazil

[10] CIBERSAM, Fdn St Joan de Deu, Parc Sanitari St Joan de Deu, Res & Dev Unit, Barcelona, Spain

[11] Univ Greenwich, Fac Educ & Hlth, London, England

[12] Univ Padua, Dept Biomed Sci, Padua, Italy

关键词: Mitochondrial haplogroups;    Depression;    Osteoarthritis initiative;   

DOI  :  10.1016/j.jad.2017.03.069

来源: Elsevier

【 摘 要 】

Background A possible relationship between mitochondrial haplogroups and psychiatric diseases (e.g. schizophrenia and bipolar disorder) has been postulated, but data regarding depression is still limited. We investigated whether any mitochondrial haplogroup carried a significant higher risk of depressive symptoms in a large prospective cohort of North American people included in the Osteoarthritis Initiative. Methods: Cross sectional data was derived from the Osteoarthritis Initiative. The haplogroup was assigned through a combination of sequencing and PCR-RFLP techniques. All the mitochondrial haplogroups were named following this nomenclature: H, U, K, J, T, V, SuperHV, I, W, X or Others. Depression was ascertained through the 20-item Center for Epidemiologic Studies-Depression (CES-D), with >= 16 indicating depressive symptoms. Results: Overall, 3601 Caucasian participants (55.9% women), mean age of 61.7 +/- 9.3 years were included. No difference was observed in mitochondrial haplogroups frequency among those with depressive symptoms (n=285, = 7.9% of the baseline population) compared to participants with no depressive symptoms (N = 3316) (chi-square test = 0.53). Using a logistic regression analysis, adjusted for eight potential confounders, with those having the haplogroup H as the reference group (the most common haplogroup), no significant mitochondrial haplogroup was associated with prevalent depressive symptoms. The same results were evident in secondary analysis in which we matched depressed and non-depressed participants for age and sex. Limitations: Cross-sectional design; only CES-D for evaluating mood; participants not totally representative of general population. Conclusions: We found no evidence of any relationship between specific mitochondrial haplogroups and depressive symptoms. Future longitudinal research is required to confirm/refute these findings.

【 授权许可】

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