Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients

JOURNAL OF AFFECTIVE DISORDERS

卷:184

Article

Belzeaux, Raoul^1,2,3  Boyer, Laurent⁴  Mazzola-Pomietto, Pascale⁵  Michel, Pierre⁴  Correard, Nadia^1,3  Aubin, Valerie^3,6  Bellivier, Frank^3,7  Bougerol, Thierry^3,16  Olie, Emilie^3,8  Courtet, Philippe^3,8  Etain, Bruno^3,13,14,15  Gard, Sebastien^3,9  Kahn, Jean-Pierre^3,10,11  Passerieux, Christine^3,12  Leboyer, Marion^3,13,14,15  Henry, Chantal^3,13,14,15  Azorin, Jean-Michel^1,3,4 

[1] Hop St Marguerite, Assistance Publ Hop Marseille, Pole Psychiat, Marseille, France

[2] Aix Marseille Univ, CNRS, UMR 7286 CRN2M, F-13344 Marseille 15, France

[3] Fdn FondaMental, Creteil, France

[4] Timone Univ, Sch Med, EA Self Perceived Hlth Assessment Res Unit 3279, Marseille, France

[5] Aix Marseille Univ, CNRS, INT UMR 7289, F-13385 Marseille 15, France

[6] Ctr Hosp Princesse Grace, Psychiat Serv, Monaco, Monaco

[7] GH St Louis Lariboisiere Fernund, AP HP, Pole Neurosci, Paris, France

[8] Univ Montpellier I, INSERM U1061, CHRU Montpellier, Dept Urgence & Post Urgence Psychiat, Montpellier, France

[9] Hop Charles Perrens, Ctr Expert Trouble Bipolaire, Serv Psychiat Adulte, Bordeaux, France

[10] Hop Brabois, CHU Nancy, Serv Psychiat & Psychol Clin, Vandoeuvre Les Nancy, France

[11] Univ Lorraine, Nancy, France

[12] Univ Versailles St Quentin, Ctr Hosp Versailles, Serv Psychiat Adulte, Le Chesnay, France

[13] INSERM, U955, Equipe Psychiat Genet, F-94000 Creteil, France

[14] Univ Paris Est, Fac Med, F-94000 Creteil, France

[15] Hop Univ Henri Mondor, AP HP, Pole Psychiat, F-94000 Creteil, France

[16] CHU Grenoble, Clin Univ Psychiat, F-38043 Grenoble, France

关键词: Substance Use Disorders;    Impulsivity;    Anxiety disorders;    Mood disorders;   

DOI  :  10.1016/j.jad.2015.05.041

来源: Elsevier

【 摘 要 】

Background: Adherence to medication is a major issue in bipolar disorder. Non planning impulsivity, defined as a lack of future orientation, has been demonstrated to be the main impulsivity domain altered during euthymia in bipolar disorder patients. It was associated with comorbidities. Methods: To investigate relationship between adherence to medication and non-planning impulsivity, we included 260 euthymic bipolar patients. Adherence to medication was evaluated by Medication Adherence Rating Scale and non-planning impulsivity by Banat Impulsiveness Scale. Univariate analyses and linear regression were used. We conducted also a path analysis to examine whether non-planning impulsivity had direct or indirect effect On adherence, mediated by comorbidities. Results: Adherence to medication was correlated with non-planning impulsivity, even after controlling for potential confounding factors in linear regression analysis (Beta standardized coefficient=0.156; p=0.015). Path analysis demonstrated only a direct effect of non-planning impulsivity on adherence to medication, and none indirect effect via substance use disorders and anxiety disorders. Limitations: Our study is limited by its cross-sectional design and adherence to medication was assessed only by self-questionnaire. Conclusions: Higher non-planning impulsivity is associated with low medication adherence, without an indirect effect via comorbidities. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free