Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder

JOURNAL OF AFFECTIVE DISORDERS

卷:126

Article

McNamara, Robert K.¹  Jandacek, Ronald²  Rider, Therese²  Tso, Patrick²  Dwivedi, Yogesh³  Pandey, Ghanshyam N.³ 

[1] Univ Cincinnati, Coll Med, Div Bipolar Disorders Res, Dept Psychiat, Cincinnati, OH 45219 USA

[2] Univ Cincinnati, Dept Pathol, Cincinnati, OH 45237 USA

[3] Univ Illinois, Dept Psychiat, Inst Psychiat, Chicago, IL 60612 USA

关键词: Bipolar disorder;    Major depressive disorder;    Erythrocyte;    Docosahexaenoic acid (DHA);    Eicosapentaenoic acid (EPA);    Arachidonic acid (AA);    Fatty acid;   

DOI  :  10.1016/j.jad.2010.03.015

来源: Elsevier

【 摘 要 】

Background: Epidemiological and controlled intervention trials suggest that omega-3 (n-3) fatty acid deficiency represents a reversible risk factor for recurrent affective disorders. However, there is limited comparative information available regarding the n-3 fatty acid status and associated mood symptoms in medication-free patients with major depressive disorder (MOD) and bipolar disorder (BD). Methods: The fatty acid composition of erythrocyte membranes from adult male and female healthy controls (n = 20) and medication-free patients with MDD (n = 20) and BD (n = 20) was determined by gas chromatography. Associations with depression and mania symptom severity scores were investigated. Results: After correction for multiple comparisons, both MDD (-20%) and BD (-32%) patients exhibited significantly lower erythrocyte docosahexaenoic acid (DHA, 22:6n-3) composition relative to healthy controls, and there was a trend for lower DHA in BD patients relative to MDD patients (-15%, p = 0.09). There were no gender differences for DHA in any group. Other n-3 fatty acids, including eicosapentaenoic acid (EPA, 20:5n-3) and docosapentanoic acid (22:5n-3), and n-6 fatty acids, including arachidonic acid (M, 20:4n-6), were not different. Erythrocyte DHA composition was inversely correlated with indices of delta-9 desaturase activity (18:1/18:0), and associated elevations in oleic acid (18:1n-9) composition, and delta-6 desaturase activity (20:3/18:2). DHA composition was not significantly correlated with depression or mania symptom severity scores. Limitations: Data regarding diet and life style factors (cigarette smoking) were not available to evaluate their contribution to the present findings. Conclusions: Male and female patients with MOD and BD exhibit selective erythrocyte DHA deficits relative to healthy controls, and this deficit was numerically greater in BD patients. Selective DHA deficits are consistent with impaired peroxisome function, which has implications for n-3 fatty acid interventions aimed at preventing or reversing this deficit. (C) 2010 Elsevier B.V. All rights reserved.

【 授权许可】

Free