Transdiagnostic treatment of bipolar disorder and comorbid anxiety using the Unified Protocol for Emotional Disorders: A pilot feasibility and acceptability trial

JOURNAL OF AFFECTIVE DISORDERS

卷:219

Article

Ellard, Kristen K.¹  Bernstein, Emily E.²  Hearing, Casey³  Baek, Ji Hyun⁴  Sylvia, Louisa G.¹  Nierenberg, Andrew A.¹  Barlow, David H.⁵  Deckersbach, Thilo¹ 

[1] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[2] Harvard Univ, Dept Psychol, 33 Kirkland St, Cambridge, MA 02138 USA

[3] George Washington Univ, Dept Psychol, Washington, DC 20052 USA

[4] Sungkyunkwan Univ, Samsung Med Ctr, Dept Psychiat, Suwon, Gyeonggi Do, South Korea

[5] Boston Univ, Dept Psychol, 64 Cummington St, Boston, MA 02215 USA

关键词: Bipolar disorder;    Anxiety disorders;    Transdiagnostic;    Cognitive behavioral therapy;    Emotion regulation;   

DOI  :  10.1016/j.jad.2017.05.011

来源: Elsevier

【 摘 要 】

Background: Comorbid anxiety in bipolar disorder (BD) is associated with greater illness severity, reduced treatment response, and greater impairment. Treating anxiety in the context of BD is crucial for improving illness course and outcomes. The current study examined the feasibility, acceptability and preliminary efficacy of the Unified Protocol (UP), a transdiagnostic cognitive behavioral therapy, as an adjunctive treatment to pharmacotherapy for BD and comorbid anxiety disorders. Methods: Twenty-nine patients with BD and at least one comorbid anxiety disorder were randomized to pharmacotherapy treatment-as-usual (TAU) or TAU with 18 sessions of the UP (UP+TAU). All patients completed assessments every four weeks to track symptoms, functioning, emotion regulation and temperament. Linear mixed-model regressions were conducted to track symptom changes over time and to examine the relationship between emotion-related variables and treatment response. Results: Satisfaction ratings were equivalent for both treatment groups. Patients in the UP+TAU group evidenced significantly greater reductions over time in anxiety and depression symptoms (Cohen's d's > 0.80). Baseline levels of neuroticism, perceived affective control, and emotion regulation ability predicted magnitude of symptom change for the UP+TAU group only. Greater change in perceived control of emotions and emotion regulation skills predicted greater change in anxiety related symptoms. Limitations: This was a pilot feasibility and acceptability trial; results should be interpreted with caution. Conclusions: Treatment with the UP+TAU was rated high in patient satisfaction, and resulted in significantly greater improvement on indices of anxiety and depression relative to TAU. This suggests that the UP may be a feasible treatment approach for BD with comorbid anxiety.

【 授权许可】

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