Maternal antenatal stress and mental and behavioral disorders in their children

JOURNAL OF AFFECTIVE DISORDERS

卷:278

Article

Tuovinen, Soile¹  Lahti-Pulkkinen, Marius¹  Girchenko, Polina¹  Heinonen, Kati¹  Lahti, Jari¹  Reynolds, Rebecca M.²  Hamalainen, Esa^3,4  Villa, Pia M.^4,5  Kajantie, Eero^{6,7,8,9,10,11}  Laivuori, Hannele^{4,12,13,14,15}  Raikkonen, Katri¹ 

[1] Univ Helsinki, Fac Med, Dept Psychol & Logoped, Helsinki, Finland

[2] Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland

[3] Univ Helsinki, Dept Clin Chem, Helsinki, Finland

[4] Helsinki Univ Hosp, Helsinki, Finland

[5] Univ Helsinki, Obstet & Gynecol, Helsinki, Finland

[6] Natl Inst Hlth & Welf, Helsinki, Finland

[7] Oulu Univ Hosp, MRC Oulu, PEDEGO Res Unit, Oulu, Finland

[8] Univ Oulu, Oulu, Finland

[9] Helsinki Univ Hosp, Childrens Hosp, Helsinki, Finland

[10] Univ Helsinki, Helsinki, Finland

[11] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway

[12] Univ Helsinki, Med & Clin Genet, Helsinki, Finland

[13] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki Inst Life Sci, Helsinki, Finland

[14] Tampere Univ Hosp, Dept Obstet & Gynecol, Tampere, Finland

[15] Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland

关键词: Fetal programming;    Mental disorders;    Prenatal stress;    Depression;    Anxiety;   

DOI  :  10.1016/j.jad.2020.09.063

来源: Elsevier

【 摘 要 】

Background: Maternal antenatal stress, including symptoms of depression, anxiety and perceived stress, is associated with mental and behavioral problems in children. Whether it is associated with child mental and behavioral disorders remains uncertain. We examined if maternal antenatal symptoms of depression, anxiety and perceived stress were associated with mental and behavioral disorders in their children, if the associations varied according to gestational week, stress type, fluctuating or consistently high symptoms, and if they were driven by maternal or paternal lifetime mood or anxiety disorders. Methods: 3365 mothers participating in the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiologic Studies Depression Scale, the State Anxiety Inventory and the Perceived Stress Scale up to 14 times throughout pregnancy. The Care Register for Health Care provided data on mental and behavioral (including neurodevelopmental) disorders for their children from birth (11/07/2006-07/24/2010) until 12/31/2016 and for parental lifetime mood and anxiety disorders until 12/31/ 2016. Results: The hazard of any childhood mental and behavioral disorder (HR=1.91, 95% CI: 1.39-2.51) was significantly higher for children whose mothers reported consistently high in comparison to consistently low levels of all types of stress throughout pregnancy. The associations remained significant when adjusted for maternal and paternal lifetime mood and anxiety disorders (and their comorbidity and timing and mood disorder type). Conclusion: Maternal antenatal stress is associated with higher risk of childhood mental and behavioral disorders. Efforts to reduce maternal antenatal stress should be given a high priority to improve child mental health.

【 授权许可】

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