Increased nitro-oxidative stress toxicity as a major determinant of increased blood pressure in mood disorders

JOURNAL OF AFFECTIVE DISORDERS

卷:278

Article

Bonifacio, Kamila Landucci^1,3  Barbosa, Decio Sabbatini^1,2,3  Moreira, Estefania Gastaldello³  Coneglian, Carine Farias^1,3  Vargas, Heber Odebrecht⁴  Nunes, Sandra Odebrecht Vargas^3,4  Moraes, Juliana Brum¹  Maes, Michael^5,6,7 

[1] Univ Estadual Londrina, Graduat Program Hlth Sci Ctr, Londrina, Parana, Brazil

[2] Univ Estadual Londrina, Dept Clin Anal & Toxicol, Londrina, Parana, Brazil

[3] Univ Estadual Londrina, Lab Grad Program Hlth Sci, Londrina, PR, Brazil

[4] Univ Estadual Londrina, Dept Psychiat, Hlth Sci Ctr, Londrina, Parana, Brazil

[5] King Chulalongkorn Mem Hosp, Dept Psychiat, Fac Med, Bangkok, Thailand

[6] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria

[7] Deakin Univ, IMPACT Strateg Res Ctr, Geelong, Vic, Australia

关键词: Major depression;    Oxidative and nitrosative stress;    Antioxidants;    Inflammation;    Neuro-immune;    Biomarkers;   

DOI  :  10.1016/j.jad.2020.09.040

来源: Elsevier

【 摘 要 】

Background: Hypertension, atherogenicity and insulin resistance are major risk factors of cardiovascular dis order (CVD), which shows a strong comorbidity with major depression (MDD) and bipolar disorder (BD). Activated oxidative and nitrosative stress (O&NS), inflammatory pathways, and increased atherogenicity are shared pathways underpinning CVD and mood disorders. Methods: The current study examined the effects of lipid hydroperoxides (LOOH), superoxide dismutase (SOD), nitric oxide metabolites (NOx), advanced oxidation protein products (AOPP), and malondialdehyde (MDA) on systolic (SBP) and diastolic (DBP) blood pressure in 96 mood disordered patients and 60 healthy controls. Results: A large part of the variance in SBP (31.6%) was explained by the regression on a z unit-weighted composite score (based on LOOH, AOPP, SOD, NOx) reflecting nitro-oxidative stress toxicity (NOSTOX), coupled with highly sensitive C-reactive protein, body weight and use of antihypertensives. Increased DBP was best predicted (23.8%) by body mass index and NOSTOX. The most important O&NS biomarkers predicting an increased SBP were in descending order of significance: LOOH, AOPP and SOD. Higher levels of the atherogenic index of plasma, HOMA2 insulin resistance index and basal thyroid-stimulating hormone also contributed to increased SBP independently from NOSTOX. Although there were no significant changes in SBP/DBP in mood disorders, the associations between NOSTOX and blood pressure were significant in patients with mood dis orders but not in healthy controls. Conclusions: Activated O&NS pathways including increased lipid peroxidation and protein oxidation, which indicates hypochlorous stress, are the most important predictors of an increased BP, especially in patients with mood disorders.

【 授权许可】

Free