Gene-by-social-environment interaction (GxSE) between ADCYAP1R1 genotype and neighborhood crime predicts major depression symptoms in trauma-exposed women

JOURNAL OF AFFECTIVE DISORDERS

卷:187

Article

Lowe, Sarah R.¹  Pothen, John²  Quinn, James W.¹  Rundle, Andrew¹  Bradley, Bekh^3,4  Galea, Sandro⁵  Ressler, Kerry J.⁴  Koenen, Karestan C.¹ 

[1] Montclair State Univ, Dept Psychol, Montclair, NJ 07043 USA

[2] Emory Univ, Sch Med, Atlanta, GA 30322 USA

[3] Atlanta Vet Affairs Med Ctr, Mental Hlth Serv Line, Decatur, GA USA

[4] Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30322 USA

[5] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02215 USA

关键词: Posttraumatic stress;    Major depression;    Genetic risk;    Social environment;    Gene-by-social-environment interactions;    Neighborhood crime;    Multilevel modeling;   

DOI  :  10.1016/j.jad.2015.08.002

来源: Elsevier

【 摘 要 】

Background: Few studies have explored interactions between genes and social environmental exposures (GxSEs) for trauma related psychopathology, including symptoms of posthaumatic stress (PTS) and major depression (MD). The extant literature suggests the possibility of a GxSE between the rs2267735 variant of the ADCYAP1R1 gene and neighborhood crime. The current study aimed to explore this possibility among a predominantly African American sample of trauma-exposed women. Methods: Female participants (N=1361) were recruited from a public hospital, and completed measures of PTS and MD symptoms and provided DNA samples. Participants' home addresses were mapped onto 300 neighborhoods (2010 census tracts), and data on crime within neighborhoods was collected. Results: Multilevel models detected a significant GxSE between rs2267735 and neighborhood crime for MD symptoms (p=.01). Having two copies of the risk (C) allele was associated with higher MD symptoms for participants living in high-crime neighborhoods. Limitations: At least six limitations are noteworthy: (1) low statistical power; (2) use of self-report symptom inventories; (3) lack of information on symptom onset; (4) homogeneous sample from a single metropolitan at (5) non-specific index of crime; and (6) use of census tracts to define neighborhoods. Conclusions: The results provide further evidence of GxSEs for psychiatric outcomes among trauma-exposed populations. Further investigations of genetic factors for trauma-related psychopathology should include careful assessments of the social environment. (C) 2015 Elsevier B.V. All rights reserved

【 授权许可】

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