The specificity of the familial aggregation of early-onset bipolar disorder: A controlled 10-year follow-up study of offspring of parents with mood disorders

JOURNAL OF AFFECTIVE DISORDERS

卷:190

Article

Preisig, Martin¹  Strippoli, Marie-Pierre F.¹  Castelao, Enrique¹  Merikangas, Kathleen Ries²  Gholam-Rezaee, Mehdi¹  Marquet, Pierre¹  Aubry, Jean-Michel³  Vandeleur, Caroline L.¹ 

[1] Univ Lausanne Hosp, Dept Psychiat, CH-1008 Prilly, Switzerland

[2] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, Bethesda, MD 20892 USA

[3] Univ Hosp Geneva, Dept Mental Hlth & Psychiat, Geneva, Switzerland

关键词: Mania;    Age of onset;    Family aggregation;    High-risk study;    Major depression;    Substance use disorders;   

DOI  :  10.1016/j.jad.2015.10.005

来源: Elsevier

【 摘 要 】

Background: Two major sources of heterogeneity of mood disorders that have been demonstrated in clinical, family and genetic studies are the mood disorder subtype (i.e. bipolar (BPD) and major depressive disorder (MDD)) and age of onset of mood episodes. Using a prospective high-risk study design, our aims were to test the specificity of the parent-child transmission of BPD and MDD and to establish the risk of psychopathology in offspring in function of the age of onset of the parental disorder. Methods: Clinical information was collected on 208 probands (n=81 with BPD, n=64 with MDD, n=63 medical controls) as well as their 202 spouses and 372 children aged 6-17 years at study entry. Parents and children were directly interviewed every 3 years (mean duration of follow-up=10.6 years). Parental age of onset was dichotomized at age 21. Results: Offspring of parents with early onset BPD entailed a higher risk of BPD HR=7.9(1.8-34.6) and substance use disorders HR=5.0(1.1-21.9) than those with later onset and controls. Depressive disorders were not significantly increased in offspring regardless of parental mood disorder subtype or age of onset. Limitations: Limited sample size, age of onset in probands was obtained retrospectively, age of onset in co-parents was not adequately documented, and a quarter of the children had no direct interview. Conclusions: Our results provide support for the independence of familial aggregation of BPD from MDD and the heterogeneity of BPD based on patterns of onset. Future studies should further investigate correlates of early versus later onset BPD. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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