Subsyndromal and syndromal depressive symptoms among older adults with schizophrenia spectrum disorder: Prevalence and associated factors in a multicenter study

JOURNAL OF AFFECTIVE DISORDERS

卷:251

Article

Hoertel, Nicolas^1,2,3  Jaffre, Claire¹  de Raykeer, Rachel Pascal^1,2  McMahon, Kibby⁴  Barriere, Sarah⁵  Blumenstock, Yvonne¹  Portefaix, Christophe^6,7  Raucher-Chene, Delphine^5,8  Bera-Potellee, Celine⁵  Cuervo-Lombard, Christine^5,9  Chevance, Astrid¹  Guerin-Langlois, Christophe^1,5  Lemogne, Cedric^1,2,3  Airagnes, Guillaume^1,3,10  Peyre, Hugo^11,12  Kaladjian, Arthur^5,8  Limsoin, Frederic^1,2,3 

[1] Western Paris Univ Hosp, AP HP, Dept Psychiat, F-92130 Issy Les Moulineaux, France

[2] INSERM UMR 894, Psychiat & Neurosci Ctr, Paris, France

[3] Paris Descartes Univ, Sorbonne Paris Cite, Paris, France

[4] Duke Univ, Dept Psychol & Neurosci, 2213 Elba St Durham, Durham, NC 27710 USA

[5] Reims Univ Hosp, Robert Debra Hosp, Dept Psychiat, Reims, France

[6] Reims Univ Hosp, Maison Blanche Hosp, Dept Med Imaging, Reims, France

[7] Univ Reims, CReST Lab, EA 3804, Reims, France

[8] Univ Reims, Cognit Hlth & Socialisat Lab, EA 6291, Reims, France

[9] Toulouse 2 Jean Allures Univ, CERPPS Lab, Dept Psychol, EA 7411, Toulouse, France

[10] INSERM, Populat Based Epidemiol Cohorts, VIMA, UMS 011,UMR 1168, Villejuif, France

[11] Robert Debra Hosp, AP HP, Child & Adolescent Psychiat Dept, Paris, France

[12] Ecole Normale Super, Cognit Sci & Psycholinguist Lab, Paris, France

关键词: Depression;    Depressive symptoms;    Schizophrenia;    Older;    Elderly;    Prevalence;    Risk factors;    Antidepressants;    Antipsychotic;    Treatment;   

DOI  :  10.1016/j.jad.2019.03.007

来源: Elsevier

【 摘 要 】

Background: Few studies have examined the prevalence and correlates of subsyndromal and syndromal depressive symptoms (SSSD) among older adults with schizophrenia spectrum disorder. In this report, we examined the prevalence of SSSD and their associations with sociodemographic characteristics, clinical characteristics of schizophrenia, comorbidity, psychotropic medications, quality of life, functioning and mental health care utilization in a large, multicenter sample of older adults with schizophrenia spectrum disorder. Methods: Data from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) were used to examine the prevalence of SSSD, defined using the Center of Epidemiologic Studies Depression (CESD) scale. Clinical characteristics associated with SSSD were explored. Results: Among 343 older adults with schizophrenia spectrum disorder, 78.1% had either subsyndromal (30.6%) or syndromal (47.5%) depressive symptoms. SSSD were independently associated with positive and negative symptoms, lower quality of life, non-late-onset psychosis, benzodiazepine use and urbanicity. There were no significant associations of SSSD with other sociodemographic characteristics and psychotropic medications, or with general medical conditions. We found no significant differences in the proportion of participants who were treated with antidepressants between those with syndromal depressive symptoms and those without depression (22.1% vs. 20.0%, p=0.89). SSSD were not associated with higher mental health care utilization. Limitations: Data were cross-sectional and depression was not evaluated with a semi-structured interview. Conclusion: SSSD may be highly prevalent and under-assessed and/or undertreated among older adults with schizophrenia spectrum disorder. Our findings should alert clinicians about the need to assess systematically and regularly depression in this vulnerable population.

【 授权许可】

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