The bidirectional relationships between alcohol, cannabis, co-occurring alcohol and cannabis use disorders with major depressive disorder: Results from a national sample

JOURNAL OF AFFECTIVE DISORDERS

卷:148

Article

Pacek, Lauren R.¹  Martins, Silvia S.^1,2  Crum, Rosa M.^1,3,4 

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21205 USA

[2] Columbia Univ, Sch Publ Hlth, Dept Epidemiol, New York, NY USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[4] Johns Hopkins Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD USA

关键词: Cannabis;    Alcohol;    Abuse;    Dependence;    Depression;    Co-occurring use;   

DOI  :  10.1016/j.jad.2012.11.059

来源: Elsevier

【 摘 要 】

Introduction: Alcohol use disorders (AUD) and cannabis use disorders (CUD) are common in the United States (US), and are associated with major depressive disorder (MDD). Co-occurring alcohol and cannabis use/use disorders (AUD + CUD), though understudied, have been found to be associated with greater adverse outcomes than alcohol or cannabis use/use disorders alone. There is a paucity of research on the co-occurring relationships of the two disorders with depression. Methods: Data came from Waves 1 and 2 of the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC), a population-based longitudinal survey of the adult non-institutionalized, civilian population in the US. Logistic regression analyses were used to assess the associations between: 1) baseline AUD, CUD, and co-occurring AUD + CUD with incident MDD at follow-up and 2) baseline MDD with incident AUD, CUD, and co-occurring AUD + CUD at follow-up, adjusted for potential confounding variables. Results: For Aim 1, most of the AUD and CUD were positively associated with MDD. The strongest associations with incident MDD were observed for cannabis dependence (OR = 6.61, CI = 1.67-26.21) and co-occurring alcohol and cannabis dependence (OR = 2.34, CI = 1.23-4.48). For Aim 2, baseline MDD was significantly associated with comparatively fewer cases of incident AUD and CUD but the strongest association was observed for new onset co-occurring alcohol and cannabis dependence (OR = 4.51, CI = 1.31-15.60). Limitations: The present study is limited by the potential for social desirability and recall biases. Discussion: Positive associations between AUD, CUD and MDD were observed bidirectionally. Findings have implications for preventive and treatment programs and initiatives. (c) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

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