Perceived life stress exposure modulates reward-related medial prefrontal cortex responses to acute stress in depression

JOURNAL OF AFFECTIVE DISORDERS

卷:180

Article

Kumar, Poornima^1,2  Slavich, George M.^3,4  Berghorst, Lisa H.⁵  Treadway, Michael T.⁶  Brooks, Nancy H.¹  Dutra, Sunny J.⁷  Greve, Douglas N.⁸  O'Donovan, Aoife^9,10  Bleil, Maria E.¹¹  Maninger, Nicole¹²  Pizzagalli, Diego A.^1,2 

[1] McLean Hosp, Ctr Depress Anxiety & Stress Res, Belmont, MA 02478 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA

[3] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[5] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA

[6] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

[7] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

[8] Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA USA

[9] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[10] San Francisco VA Med Ctr, San Francisco, CA USA

[11] Univ Washington, Dept Family & Child Nursing, Seattle, WA 98195 USA

[12] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA

关键词: Stress;    Depression;    Anhedonia;    Life events;    fMRI;    Reward processing;   

DOI  :  10.1016/j.jad.2015.03.035

来源: Elsevier

【 摘 要 】

Introduction: Major depressive disorder (MDD) is often precipitated by life stress and growing evidence suggests that stress induced alterations in reward processing may contribute to such risk. However, no human imaging studies have examined how recent life stress exposure modulates the neural systems that underlie reward processing in depressed and healthy individuals. Methods: In this proof-of-concept study, 12 MDD and 10 psychiatrically healthy individuals were interviewed using the Life Events arid Difficulties Schedule (LEDS) to assess their perceived levels of recent acute and chronic life stress exposure. Additionally, each participant performed a monetary incentive delay task under baseline (no stress) and stress (social evaluative) conditions during functional MRL Results: Across groups, medial prefrontal cortex (mPFC) activation to reward feedback was greater during acute stress versus no-stress conditions in individuals with greater perceived stressor severity. Under acute stress, depressed individuals showed a positive correlation between perceived stressor severity levels and reward-related mPFC activation (r=0.79, p=0.004), whereas no effect was found in healthy controls. Moreover, for depressed (but not healthy) individuals, the correlations between the stress (r=0.79) and no-stress (r=0.48) conditions were significantly different. Finally, reMtive to controls, depressed participants showed significantly reduced mPFC gray matter, but functional findings remained robust while accounting for structural differences. Limitation: Small sample size, which warrants replication. Conclusion: Depressed individuals experiencing greater recent life stress recruited the mPFC more under stress when processing rewards. Our results represent an initial step toward elucidating mechanisms underlying stress sensitization and recurrence in depression. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free