White matter abnormalities in the fornix are linked to cognitive performance in SZ but not in BD disorder: An exploratory analysis with DTI deterministic tractography

JOURNAL OF AFFECTIVE DISORDERS

卷:201

Article

Knoechel, Christian¹  Schmied, Claudia¹  Linden, David E. J.³  Staeblein, Michael¹  Prvulovic, David¹  de Carvalho, Luiza de A.^4,5  Harrison, Octavia^1,2  Barros Junior, Paulo O.^4,5  Carvalho, Andre F.^4,5  Reif, Andreas¹  Alves, Gilberto S.^4,5  Oertel-Knoehel, Viola¹ 

[1] Goethe Univ Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Lab Neuroimaging, D-60054 Frankfurt, Germany

[2] Goethe Univ Frankfurt, Brain Imaging Ctr, D-60054 Frankfurt, Germany

[3] Cardiff Univ, Sch Med, Inst Psychol Med & Clin Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

[4] Univ Fed Ceara, Fac Med, Translat Psychiat Res Grp, Fortaleza, Ceara, Brazil

[5] Univ Fed Ceara, Fac Med, Dept Clin Med, Fortaleza, Ceara, Brazil

关键词: Structural Imaging;    Bipolar;    Psychosis;    Fiber tracking;    Deterministic tractography;    Cognition;   

DOI  :  10.1016/j.jad.2016.03.015

来源: Elsevier

【 摘 要 】

Background: In psychosis, white matter (WM) microstructural changes have been detected previously; however, direct comparisons of findings between bipolar (BD) and schizophrenia (SZ) patients are scarce. In this study, we employed deterministic tractography to reconstruct WM tracts in BD and SZ patients. Methods: Diffusion tensor imaging (DTI) data was carried out with n=32 euthymic BD type I patients, n=26 SZ patients and 30 matched healthy controls. Deterministic tractography using multiple indices of diffusion (fractional anisotropy (FA), tract volume (Vol), tract length (Le) and number of tracts (Noir)) were obtained from the fornix, the cingulum, the anterior thalamic radiation, and the corpus callosum bilaterally. Results: We showed widespread WM microstructural changes in SZ, and changes in the corpus callosum, the left cingulum and the fornix in BD. Fornix fiber tracking scores were associated with cognitive performance in SZ, and with age and age at disease onset in the BD patient group. Limitations: Although the influence of psychopharmacological drugs as biasing variables on morphological alterations has been discussed for SZ and BD, we did not observe a clear influence of drug exposure on our findings. Conclusions: These results confirm the assumption that SZ patients have more severe WM changes than BD patients. The findings also suggest a major role of WM changes in the fornix as important fronto-limbic connections in the etiology of cognitive symptoms in SZ, but not in BD. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free