CHANGES IN EEG POWER-DENSITY OF NON-REM SLEEP IN DEPRESSED-PATIENTS DURING TREATMENT WITH TRAZODONE

JOURNAL OF AFFECTIVE DISORDERS

卷:35

Article

VANBEMMEL, AL ; BEERSMA, DGM ; VANDENHOOFDAKKER, RH

关键词: DEPRESSION;    ANTIDEPRESSANT;    TRAZODONE;    SLEEP;    EEG;    SPECTRAL ANALYSIS;   

DOI  :  10.1016/0165-0327(95)00033-J

来源: Elsevier

【 摘 要 】

Recently, it was hypothesized that acute or cumulative suppression of non-REM sleep intensity might be related to the therapeutic effects of antidepressants. This intensity has been proposed to be expressed in the EEG power density in non-REM sleep. In the present study, the relationship was examined between the changes of EEG power density in non-REM sleep and the changes in clinical state in 8 depressed patients during treatment with trazodone. A 1-week wash-out period was followed by 1 week of placebo administration, a medication period of 5 weeks and a 1-week placebo period. To minimize systematic influences of sleep duration and non-REM-REM sleep alterations, EEG power was measured over the longest common amount of non-REM sleep stages 2-4 (168.5 min), accumulated from sleep onset onwards. During trazodone treatment, the 13-and 14-Hz bins showed a significant reduction in EEG power. No clear-cut change, however, was observed in the EEG power of the delta frequency range (1-4 Hz) which is considered to be the principle manifestation of non-REM sleep intensity. Furthermore, no overall significant relationship between EEG power suppression and clinical improvement could be demonstrated.

【 授权许可】

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