Impulsivity and its association with childhood trauma experiences across bipolar disorder, attention deficit hyperactivity disorder and borderline personality disorder

JOURNAL OF AFFECTIVE DISORDERS

卷:244

Article

Richard-Lepouriel, Helene¹  Kung, Anne-Lise²  Hasler, Roland²  Bellivier, Frank^3,4  Prada, Paco¹  Gard, Sebastien^3,5  Ardu, Stefano^6,7  Kahn, Jean-Pierre^3,8  Dayer, Alexandre^1,2  Henry, Chantal^9,10,11  Aubry, Jean-Michel^1,2  Leboyer, Marion^3,9,10  Perroud, Nader¹  Etain, Bruno^3,4,12 

[1] Univ Hosp Geneva, Dept Mental Hlth & Psychiat, Serv Psychiat Specialties, Geneva, Switzerland

[2] Univ Geneva, Fac Med, Dept Psychiat, Geneva, Switzerland

[3] Fdn Fondamental, Creteil, France

[4] Univ Paris Diderot, Dept Psychiat & Med Addictol, Sorbonne Paris Cite, AP HP,GH St Louis Lariboisiere Fernand Widal, Paris, France

[5] Hop Charles Perrens, Serv Psychiat Adulte, Pole 3-4-7, F-33000 Bordeaux, France

[6] Univ Geneva, Dent Sch, Treatment Plan Unit, Dept Cardiol & Endodontol, Geneva, Switzerland

[7] Univ Geneva, Dent Sch, Div Operat Dent, Geneva, Switzerland

[8] Hop Brabois, CHU Nancy, Serv Psychiat & Psychol Clin, F-54500 Vandoeuvre Les Nancy, France

[9] INSERM, Equipe Psychiat Translat, U955, Creteil, France

[10] Univ Paris Est, Fac Med, Pole Psychiat & Addictol, Hop Univ Henri Mondor,AP HP,DHU Pepsy, Creteil, France

[11] Inst Pasteur, Unite Percept & Memoire, Paris, France

[12] INSERM, UMR S1144, Paris, France

关键词: Psychiatry;    ADHD;    Mood disorders;    Borderline personality disorder;    Impulsivity;    Childhood trauma;   

DOI  :  10.1016/j.jad.2018.07.060

来源: Elsevier

【 摘 要 】

Background: Impulsivity is a core feature of the attention-deficit/hyperactivity disorder (ADHD) and is one of the DSM-V diagnostic criteria for borderline personality disorder (BPD). Impulsivity is also present in bipolar disorder (BD). Impulsivity has been linked to adverse behavior (suicidality,...) and to traumatic childhood experiences. Our study explored impulsivity in BPD, BD, ADHD and healthy controls (CTRL) and investigated the impact of early trauma on impulsivity. Methods: 744 patients with BD (n = 276), BPD (n = 168), ADHD (n = 173) or a combination (BPD_BD, n = 29; BPD_ADHD, n = 94, BD_BPD_ADHD n = 13) and 47 controls were included. All subjects were completed the Baratt Impulsivity Scale (BIS-10) and the Childhood Trauma Questionnaire (CTQ). Results: BD reported the same levels of impulsiveness as CTRL. When BPD and BD are co-morbid, impulsivity increased to reach the level of BPD. Impulsiveness was significantly associated to traumatic childhood event for BD and CTRL, not for BPD and AHDH. Limitations: Impulsivity was assessed on the basis of a self-report questionnaire and not by the mean of an objective measure such as a neuropsychological test. Moreover, we don't know what treatment our pathological subjects were receiving. But, ADHD and BPD, despite the probable treatment, were more impulsive than healthy CTRLs who did not take medications. Conclusions: Impulsivity is probably not a feature of BD but is associated with the presence of traumatic childhood experiences, especially for euthymic patients, unlike BPD and ADHD. So, it seems essential to assess the presence of early trauma to reduce the impulsivity and improve the evolution of BD.

【 授权许可】

Free