Subregional hippocampal deformations in major depressive disorder

JOURNAL OF AFFECTIVE DISORDERS

卷:126

Article

Cole, James¹  Toga, Arthur W.²  Hojatkashani, Cornelius²  Thompson, Paul²  Costafreda, Sergi G.¹  Cleare, Anthony J.¹  Williams, Steven C. R.¹  Bullmore, Edward T.³  Scott, Jan L.⁴  Mitterschiffthaler, Martina T.¹  Walsh, Nicholas D.⁵  Donaldson, Catherine¹  Mirza, Mubeena²  Marquand, Andre¹  Nosarti, Chiara¹  McGuffin, Peter¹  Fu, Cynthia H. Y.¹ 

[1] Kings Coll London, Inst Psychiat, London SE5 8AF, England

[2] Univ Calif Los Angeles, Lab NeuroImaging, Los Angeles, CA USA

[3] Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Brain Mapping Unit, Cambridge CB2 2QQ, England

[4] Newcastle Univ, Royal Victoria Infirm, Univ Dept Psychiat, Newcastle Upon Tyne, Tyne & Wear, England

[5] Univ Cambridge, Dept Psychiat, Dev Psychiat Sect, Cambridge, England

关键词: Depression;    Hippocampus;    Morphology;    Shape;    MRI;   

DOI  :  10.1016/j.jad.2010.03.004

来源: Elsevier

【 摘 要 】

Background: Hippocampal atrophy is a well reported feature of major depressive disorder, although the evidence has been mixed. The present study sought to examine hippocampal volume and subregional morphology in patients with major depressive disorder, who were all medication-free and in an acute depressive episode of moderate severity. Methods: Structural magnetic resonance imaging scans were acquired in 37 patients (mean age 42 years) and 37 age, gender and IQ-matched healthy individuals. Hippocampal volume and subregional structural differences were measured by manual tracings and identification of homologous surface points to the central core of each hippocampus. Results: Both right (P = 0.001) and left (P = 0.005) hippocampal volumes were reduced in patients relative to healthy controls (n = 37 patients and n = 37 controls), while only the right hippocampus (P = 0.016) showed a reduced volume in a subgroup of first-episode depression patients (n = 13) relative to healthy controls. Shape analysis localised the subregional deformations to the subiculum and CA1 subfield extending into the CA2-3 subfields predominantly in the tail regions in the right (P = 0.017) and left (P = 0.011) hippocampi. Limitations: As all patients were in an acute depressive episode, effects associated with depressive state cannot be distinguished from trait effects. Conclusions: Subregional hippocampal deficits are present early in the course of major depression. The deformations may reflect structural correlates underlying functional memory impairments and distinguish depression from other psychiatric disorders. (C) 2010 Elsevier B.V. All rights reserved.

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