Younger or older parental age and risk of suicidality, premature death, psychiatric illness, and criminality in offspring

JOURNAL OF AFFECTIVE DISORDERS

卷:208

Article

Mok, Pearl L. H.¹  Antonsen, Sussie^2,3  Pedersen, Carsten Bocker^2,3  Webb, Roger T.¹ 

[1] Univ Manchester, Ctr Mental Hlth & Safety, Jean McFarlane Bldg,Oxford Rd, Manchester M13 9PL, Lancs, England

[2] Aarhus Univ, Ctr Integrated Register Based Res, CIRRAU, Aarhus, Denmark

[3] Aarhus Univ, Natl Ctr Register Based Res, Business & Social Sci, Fuglesangs Alle 4, DK-8210 Aarhus V, Denmark

关键词: Maternal age;    Paternal age;    Suicidality;    Psychiatric disorder;    Premature mortality;    Criminality;   

DOI  :  10.1016/j.jad.2016.10.001

来源: Elsevier

【 摘 要 】

Background: Younger or older parental age has been linked with a range of adverse offspring endpoints. We investigated associations between parental age and nine adverse offspring outcomes in three correlated domains: (i) Premature death: suicide, unnatural death, natural death; (ii) Psychiatric morbidity: any mental illness, suicide attempt, substance misuse; (iii) Criminality: violent offending, imprisonment, driving whilst intoxicated. Methods: Persons born in Denmark 1966-1996 were followed from their 15th until 40th birthday or December 2011 (N=1,793,681). Incidence rate ratios were estimated. Results: Offspring of teenage mothers had the greatest risks for all nine adverse outcomes, especially for imprisonment, violent offending, substance misuse, and attempted suicide. Teenage fatherhood was also associated with elevated risks for offspring adverse psychiatric and criminality outcomes, but not premature mortality (at ages 15-39 years). For the psychiatric and criminality outcomes there was a U-shape trend linked with paternal age, but risks for premature mortality tended to increase with rising paternal age. On the contrary, maternal age 30 years and over was not linked with raised risks for any of the outcomes examined. Limitations: Parental links are based on legal and not biological relationships. Conclusions: The substantially elevated risks linked with teenage motherhood for a variety of poor offspring outcomes is a concern for clinicians and policymakers. The associations observed across such a wide array of adverse outcomes also suggest that multiple causal mechanisms may be implicated.

【 授权许可】

Free