Sequence of improvement in depressive symptoms across cognitive therapy and pharmacotherapy

JOURNAL OF AFFECTIVE DISORDERS

卷:110

Article

Bhar, Sunil S.¹  Schmid, Sabine P.²  Gallop, Robert³  Hollon, Steven D.⁴  Shelton, Richard C.⁴ 

[1] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

[2] Univ Illinois, Chicago, IL USA

[3] W Chester Univ Penn, Chester, PA USA

[4] Vanderbilt Univ, Nashville, TN USA

关键词: depression;    cognitive therapy;    pharmacotherapy;    symptom change;   

DOI  :  10.1016/j.jad.2007.12.227

来源: Elsevier

【 摘 要 】

Background: The authors examined the patterns of improvement in cognitive and vegetative symptoms of major depression in individuals treated with cognitive therapy (CT) or pharmacotherapy (PT). Method: Outpatients diagnosed with major depressive disorder (n = 180) were randomized to receive either CT or PT. Cognitive and vegetative symptoms of major depression were measured by the Beck Depression Inventory-II at baseline and regularly throughout 16 weeks of treatment. Results: Multivatiate hierarchical linear modeling demonstrated the same patterns of change over time for cognitive and vegetative symptoms within CT and within PT. Limitations: Self-report measures may not be sufficiently specific to capture subtle differences in improvements between vegetative and cognitive symptoms. Conclusions: These results are consistent with Beck's [Beck, A.T., 1994, November. Cognition and theory [Letter to the editor]. Arch. Gen. Psychiatry 41, 1112-1114.] hypothesis that CT and PT have a similar site of action, which when targeted, results in changes in both cognitive and vegetative features. (C) 2007 Elsevier B.V. All rights reserved.

【 授权许可】

Free