A 12-month naturalistic observation of three patients receiving repeat intravenous ketamine infusions for their treatment-resistant depression

JOURNAL OF AFFECTIVE DISORDERS

卷:147

Article

Szymkowicz, Sarah M.¹  Finnegan, Nora²  Dale, Roman M.² 

[1] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA

[2] Cleveland Clin Fdn, Lutheran Hosp, Behav Hlth Serv, Cleveland, OH 44113 USA

关键词: Ketamine;    Treatment-resistant depression;    Repeat infusions;    Depression;   

DOI  :  10.1016/j.jad.2012.10.015

来源: Elsevier

【 摘 要 】

Background: cute administration of subanesthestic doses of intravenous ketamine have been shown to elicit a rapid antidepressant response in patients with treatment-resistant depression. However, it remains to be seen if repeated doses over a longer period of time will have the same effects. Here, we assess the long-term efficacy of repeated intravenous ketamine infusions in three patients with high treatment-resistant depression via a naturalistic observation study. Method: Three patients consented to intravenous ketamine infusions as a therapy for their treatment-resistant depression. Patients were administered ketamine at 0.5 mg/kg of ideal body weight over 40 min followed by a saline flush until discharge. Severity of depressive symptoms was rated with the Montgomery-Asberg Depression Rating Scale. Results: All three patients responded to the ketamine infusions, but each went through an individualized course of treatment based on their own response. Limitations: This was an open-label naturalistic observation without blinding, randomization, or a placebo control. Conclusions: These cases add to the literature supporting the therapeutic effect of low-dose repeated intravenous ketamine for patients with treatment-resistant depression. Further study is needed to define the risks, benefits, indications, and contraindications of this potential treatment. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

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